Local auxin competition explains fragmented differentiation patterns.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_91DDD8CDC42D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Local auxin competition explains fragmented differentiation patterns.
Périodique
Nature communications
Auteur(s)
Moret B., Marhava P., Aliaga Fandino A.C., Hardtke C.S., Ten Tusscher KHW
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Statut éditorial
Publié
Date de publication
11/06/2020
Peer-reviewed
Oui
Volume
11
Numéro
1
Pages
2965
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Trajectories of cellular ontogeny are tightly controlled and often involve feedback-regulated molecular antagonism. For example, sieve element differentiation along developing protophloem cell files of Arabidopsis roots requires two antagonistic regulators of auxin efflux. Paradoxically, loss-of-function in either regulator triggers similar, seemingly stochastic differentiation failures of individual sieve element precursors. Here we show that these patterning defects are distinct and non-random. They can be explained by auxin-dependent bistability that emerges from competition for auxin between neighboring cells. This bistability depends on the presence of an auxin influx facilitator, and can be triggered by either flux enhancement or repression. Our results uncover a hitherto overlooked aspect of auxin uptake, and highlight the contributions of local auxin influx, efflux and biosynthesis to protophloem formation. Moreover, the combined experimental-modeling approach suggests that without auxin efflux homeostasis, auxin influx interferes with coordinated differentiation.
Pubmed
Open Access
Oui
Création de la notice
25/06/2020 16:10
Dernière modification de la notice
30/04/2021 7:12
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