Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice

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Version: Final published version
ID Serval
serval:BIB_91AE11F1BBE8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice
Périodique
Journal of Neuroscience
Auteur(s)
Laurent  A., Goaillard  J. M., Cases  O., Lebrand  C., Gaspar  P., Ropert  N.
ISSN
1529-2401 (Electronic)
Statut éditorial
Publié
Date de publication
02/2002
Volume
22
Numéro
3
Pages
886-900
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb 1
Résumé
The disruptive effect of excessive serotonin (5-HT) levels on the development of cortical sensory maps is mediated by 5-HT1B receptors, as shown in barrelless monoamine oxidase A knock-out mice, in which the additional inactivation of 5-HT1B receptors restores the barrels. However, it is unclear whether 5-HT1B receptors mediate their effect on barrel formation by a trophic action or an activity-dependent effect. To test for a possible effect of 5-HT1B receptors on activity, we studied the influence of 5-HT on the thalamocortical (TC) synaptic transmission in layer IV cortical neurons. In TC slices of postnatal day 5 (P5)-P9 neonate mice, we show that 5-HT reduces monosynaptic TC EPSCs evoked by low-frequency internal capsule stimulation and relieves the short-term depression of the EPSC evoked by high-frequency stimulation. We provide evidence that 5-HT decreases the presynaptic release of glutamate: 5-HT reduces similarly the AMPA-kainate and NMDA components and the paired pulse depression of TC EPSCs. We show also that 5-HT1B receptors mediate exclusively the effect of 5-HT: first, the effect of 5-HT on the TC EPSC is correlated with the transient expression of 5-HT1B receptor mRNAs in the ventrobasal thalamic nucleus during postnatal development; second, it is mimicked by a 5-HT1B agonist; third, 5-HT has no effect in 5-HT1B receptor knock-out mice. Our results show that in the developing barrel field of the neonatal mice, 5-HT1B receptors mediate an activity-dependent regulation of the TC EPSC that could favor the propagation of high-frequency TC activity.
Mots-clé
Aging/metabolism Animals Animals, Newborn Electric Stimulation Excitatory Postsynaptic Potentials/drug effects/physiology Mice Mice, Inbred Strains Mice, Knockout Neural Inhibition/drug effects Neurons/drug effects/metabolism Patch-Clamp Techniques Presynaptic Terminals/drug effects/*metabolism Pyridines/pharmacology Pyrroles/pharmacology RNA, Messenger/metabolism Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D Receptors, Serotonin/deficiency/genetics/*metabolism Serotonin/pharmacology Serotonin Agonists/pharmacology Somatosensory Cortex/drug effects/*physiology Synaptic Transmission/drug effects/*physiology Thalamus/drug effects/growth & development/*physiology Ventral Thalamic Nuclei/growth & development/metabolism
Pubmed
Web of science
Création de la notice
24/01/2008 15:27
Dernière modification de la notice
20/08/2019 15:54
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