Repeated contact with several substances can induce chemical leucoderma, often caused by derivatives of
phenols and catechols.
As well as being widely used as casting resins in the production of plastic materials, phenol formaldehyde
resins are also present in lacquers, varnishes, and adhesives.p-tert-Butylcatechol (PTBC) is a strong contact
sensitizer that is a component of p-tert-butylphenol formaldehyde resins (PTBF). PTBC is also used as an
antioxidant to stabilize other monomers in the production of plastics and rubber.
Here, we describe a case of allergic contact dermatitis followed by leucoderma caused by the use of spectacle
frames, with sensitization and exposure to phenolic compounds contained in the varnish of the spectacle
frames.