Hepatitis E virus: a zoonosis adapting to humans.

Détails

ID Serval
serval:BIB_91830E75E681
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Hepatitis E virus: a zoonosis adapting to humans.
Périodique
Journal of Antimicrobial Chemotherapy
Auteur(s)
Bihl F., Negro F.
ISSN
1460-2091[electronic], 0305-7453[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
65
Numéro
5
Pages
817-821
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
Hepatitis E virus (HEV) infection is gaining global attention, not only because of the increasing burden of the disease in low endemicity countries, in terms of morbidity and mortality rates, but also due to recent advances in the molecular virology and epidemiology of this emerging pathogen. HEV infection spread can be described as the evolution of a zoonosis towards an established human infection. As known from other viruses, such as the human immunodeficiency virus or the influenza viruses, crossing the species barriers from animals to humans is a recurrent phenomenon. Albeit slow at the beginning, once the virus has adapted to humans, the person-to-person spread can proceed very quickly. Although an optimal cell culture system for HEV is not yet available, outstanding progress has been made with the in vitro expression of HEV-like particles. These new tools have fostered new research to understand the molecular, structural and immunological aspects of human HEV infection. Although some promising data from Phase II vaccine trials are available, recent discoveries will certainly open new avenues for HEV-specific prophylaxis and therapy.
Mots-clé
Animals, Hepatitis E/epidemiology, Hepatitis E/immunology, Hepatitis E virus/classification, Hepatitis E virus/immunology, Humans, Molecular Epidemiology, Virosomes/genetics, Virus Cultivation, Zoonoses/epidemiology, Zoonoses/virology
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/02/2011 14:56
Dernière modification de la notice
20/08/2019 15:54
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