Characterization of nuclear size, ploidy, DNA histogram type and proliferation index in 79 nerve sheath tumors.

Détails

ID Serval
serval:BIB_90F7CE90EC46
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Characterization of nuclear size, ploidy, DNA histogram type and proliferation index in 79 nerve sheath tumors.
Périodique
Anticancer Research
Auteur⸱e⸱s
Salmon I., Kiss R., Segers V., Carroyer J.M., Levivier M., Pasteels J.L., Brotchi J., Flament-Durand J.
ISSN
0250-7005 (Print)
ISSN-L
0250-7005
Statut éditorial
Publié
Date de publication
1992
Peer-reviewed
Oui
Volume
12
Numéro
6B
Pages
2277-2283
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The distribution values of ploidy, of the DNA histogram type, of the proliferation index and of the nuclear area are described in a series of 79 nerve sheath tumors including 7 traumatic neuromas, 55 primary and 9 recurrent benign schwannomas, 5 benign neurofibromas and 3 malignant tumors. The nuclear parameters were computed on Feulgen-stained nuclei (from archival formalin-fixed paraffin-embedded materials) by means of digital cell image analysis. The results show that 20-30% of benign nerve sheath tumors exhibit an abnormal nuclear DNA content (DNA index > 1.30). Such a feature was observed in the four groups of benign tumors, i.e. primary and recurrent schwannomas, neurofibromas and even traumatic neuromas. Aneuploid tumors exhibited triploid, hypertriploid or polymorphic DNA histogram types. The three malignant tumors under study were aneuploid. Lastly, the nuclear area and proliferation index measurements did not allow any clear distinction to be made between the four groups of benign tumors on the one hand, and between the benign and malignant tumors on the other.
Mots-clé
Adult, Brain Diseases/pathology, Brain Neoplasms/pathology, Brain Neoplasms/surgery, Cell Nucleus/ultrastructure, DNA, Neoplasm/analysis, Female, Humans, Male, Middle Aged, Mitotic Index, Neurilemmoma/pathology, Neurilemmoma/surgery, Neurofibroma/pathology, Neurofibroma/surgery, Neuroma/pathology, Neuroma/surgery, Ploidies, Recurrence, Retrospective Studies
Pubmed
Web of science
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
20/08/2019 15:54
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