Nekrotisierende Skleritis und periphere ulzerative Keratitis mit rheumatoider Arthritis: Therapie mit Rituximab [Necrotising Scleritis and Peripheral Ulcerative Keratitis Associated with Rheumatoid Arthritis Treated with Rituximab]

Détails

ID Serval
serval:BIB_90CE15268E75
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nekrotisierende Skleritis und periphere ulzerative Keratitis mit rheumatoider Arthritis: Therapie mit Rituximab [Necrotising Scleritis and Peripheral Ulcerative Keratitis Associated with Rheumatoid Arthritis Treated with Rituximab]
Périodique
Klinische Monatsblatter fur Augenheilkunde
Auteur⸱e⸱s
Hardy S., Hashemi K., Catanese M., Candil M., Zufferey P., Gabison E., Guex-Crosier Y.
ISSN
1439-3999 (Electronic)
ISSN-L
0023-2165
Statut éditorial
Publié
Date de publication
04/2017
Peer-reviewed
Oui
Volume
234
Numéro
4
Pages
567-570
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
javax.xml.bind.JAXBElement@44635f29
Rheumatoid arthritis is a chronic and common inflammatory autoimmune disease. This primarily involves the synovia of the joints, but can cause many extra-articular manifestations as well, including peripheral ulcerative keratitis (PUK) and necrotising scleritis. These are often a threat to vision; they significantly compromise not only the eye's structural integrity but are also important for prognosis and need urgent management. javax.xml.bind.JAXBElement@3c183cd9 Three cases of peripheral ulcerative keratitis associated with rheumatoid arthritis were recorded in the electronic databank of the Jules Gonin Uveitis Clinic, two with necrotising scleritis and peripheral ulcerative keratitis and one with only peripheral ulcerative keratitis. They were all followed at Jules Gonin Eye Hospital (Lausanne, Switzerland), conjointly with the Department of Rheumatology at the Centre Hospitalier Universitaire Vaudois (Lausanne, Switzerland). javax.xml.bind.JAXBElement@745f6dd4 Good initial therapeutic response was observed in the two patients who received rituximab therapy. The patient who received only high dose corticosteroid developed massive colon perforation as well as acute renal insufficiency a few days after her ocular event. javax.xml.bind.JAXBElement@29ca34e9 From our limited number of patients, we found that the two patients who received the induction therapy with rituximab were stabilised from an ocular standpoint; however, rituximab had to be switched to other molecules, either due to other systemic symptoms from the disease itself or due to adverse effect of this treatment. This contributes to the increasing number of reports that rituximab can be an effective treatment for refractory ocular complications of rheumatoid arthritis (RA), at least as an induction therapy.

Mots-clé
Aged, Aged, 80 and over, Antirheumatic Agents/administration & dosage, Arthritis, Rheumatoid/complications, Arthritis, Rheumatoid/diagnosis, Arthritis, Rheumatoid/drug therapy, Corneal Ulcer/complications, Corneal Ulcer/diagnosis, Corneal Ulcer/drug therapy, Diagnosis, Differential, Female, Humans, Immunosuppressive Agents/administration & dosage, Rituximab/administration & dosage, Scleritis/complications, Scleritis/diagnosis, Scleritis/drug therapy, Treatment Outcome
Pubmed
Web of science
Création de la notice
07/02/2017 17:48
Dernière modification de la notice
20/08/2019 14:54
Données d'usage