From June 1 to 3, 2022, Lausanne held the spring congress of the Swiss Society of General Internal Medicine: "Changes and Opportunities". In this article, chief residents in internal medicine at CHUV summarize presentations they attended. Internal general medicine is established in french-speaking Switzerland as a transversal specialty, which is reflected in this synthesis with very varied subjects. In thromboembolic disease, the duration of anticoagulation is now based on risk of recurrence. The thrombotic microangiopathy benefit nowadays from targeted therapy which improve diseases' outcomes. The new anti-viral therapy against SARS-CoV-2 (nirmatrelvir/ritonavir) is associated with numerous drug interactions. Finally, professors from Switzerland and abroad give their advices for scientific writing and academic career initiation.