Studies on subjective well-being (SWB) have become increasingly common from a life course perspective over the last 20 years. From that perspective, individuals’ SWB is viewed as sensitive to different stressors generated by critical life course events/transitions or daily life activities, depending on the life course status under examination (Clausen, 1998; Turner & Schieman, 2008). Elder and Giele (2009) emphasized the dynamic relationship between stressors generated by changes within the life course and the consequences of such stressors on SWB, underlining that “stressors affect people’s lives while life transitions entail stressful adaptations” (Elder & Giele, 2009, p. 18). 2017; Spini & Widmer, this volume), this chapter aims to review the main findings of projects at LIVES1 dealing with the dynamic relationships between family life in mid-adulthood and changes in SWB. In this context, SWB is primarily considered as an outcome resulting from a combined effect of stressors and individual resources and reserves. The first section of this chapter defines the concept of SWB used at LIVES and outlines the general vulnerability framework. The following sections review the three main research directions taken by LIVES scholars to better understand the dynamics of the relationship between resources and SWB. The second section deals with the influence of life course family events/transitions, while the third deals with relations between daily family life and chronic strains. The fourth section highlights the mediating effect of institutional context on the previous relationships.