Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection.

Détails

ID Serval
serval:BIB_908B8C88A91A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection.
Périodique
Journal of Infectious Diseases
Auteur⸱e⸱s
Bochud P.Y., Magaret A.S., Koelle D.M., Aderem A., Wald A.
ISSN
0022-1899
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
196
Numéro
4
Pages
505-509
Langue
anglais
Résumé
Clinical and virologic manifestations of genital herpes simplex virus type 2 (HSV-2) infection vary widely. We examined frequencies of single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) 2, 3, 4, and 9 in a prospective cohort of 128 HSV-2-infected persons whose viral shedding and lesion frequency was measured by daily sampling from genital secretions. Two TLR2 haplotypes (2 and 4) were associated with increased lesional (P=.008 and P=.03) and shedding (P=.02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection.
Mots-clé
Adult, Aged, Cohort Studies, DNA, Viral, Disease Progression, Female, Genetic Predisposition to Disease, Haplotypes, Herpes Genitalis, Herpesvirus 2, Human, Humans, Male, Polymerase Chain Reaction, Polymorphism, Genetic, Prospective Studies, Toll-Like Receptor 2
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/02/2009 12:25
Dernière modification de la notice
20/08/2019 14:54
Données d'usage