Candida colonization index and subsequent infection in critically ill surgical patients: 20 years later.

Détails

Ressource 1Télécharger: BIB_907711BC5DE5.P001.pdf (1131.28 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_907711BC5DE5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Candida colonization index and subsequent infection in critically ill surgical patients: 20 years later.
Périodique
Intensive Care Medicine
Auteur⸱e⸱s
Eggimann P., Pittet D.
ISSN
1432-1238 (Electronic)
ISSN-L
0342-4642
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
40
Numéro
10
Pages
1429-1448
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
INTRODUCTION: For decades, clinicians dealing with immunocompromised and critically ill patients have perceived a link between Candida colonization and subsequent infection. However, the pathophysiological progression from colonization to infection was clearly established only through the formal description of the colonization index (CI) in critically ill patients. Unfortunately, the literature reflects intense confusion about the pathophysiology of invasive candidiasis and specific associated risk factors.
METHODS: We review the contribution of the CI in the field of Candida infection and its development in the 20 years following its original description in 1994. The development of the CI enabled an improved understanding of the pathogenesis of invasive candidiasis and the use of targeted empirical antifungal therapy in subgroups of patients at increased risk for infection.
RESULTS: The recognition of specific characteristics among underlying conditions, such as neutropenia, solid organ transplantation, and surgical and nonsurgical critical illness, has enabled the description of distinct epidemiological patterns in the development of invasive candidiasis.
CONCLUSIONS: Despite its limited bedside practicality and before confirmation of potentially more accurate predictors, such as specific biomarkers, the CI remains an important way to characterize the dynamics of colonization, which increases early in patients who develop invasive candidiasis.
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/10/2014 19:48
Dernière modification de la notice
20/08/2019 15:53
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