Bradykinin and hypoxemia-induced renal changes in the newborn rabbit.

Détails

ID Serval
serval:BIB_9056
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Bradykinin and hypoxemia-induced renal changes in the newborn rabbit.
Périodique
Pediatric Nephrology
Auteur(s)
Tóth-Heyn P., Viani M.T., Guignard J.P.
ISSN
0931-041X
Statut éditorial
Publié
Date de publication
1998
Volume
12
Numéro
5
Pages
377-380
Langue
anglais
Résumé
Acute hypoxemia causes a decrease in glomerular filtration rate (GFR) and renal blood flow (RBF) in newborns. These changes are partly mediated by local-acting vasoactive factors. We have previously shown that bradykinin (BK) has a vasodilatory role in the basic regulation of neonatal hemodynamics. The purpose of the present study was to evaluate whether BK can modulate the severe renal vasoconstriction associated with hypoxemia in the newborn rabbit. The effect of systemic hypoxemia (PaO2 approximately 40 mmHg) on renal function was investigated in 9 newborn rabbits (controls) and in 8 animals in which BK-B2 receptors were blocked by Hoe 140 (300 microg/kg subcutaneously), given prior to the induction of hypoxemia. The studies were performed under pentobarbital anesthesia at the age of 5-9 days. In control animals, acute hypoxemia caused a significant decrease in GFR and RBF and an increase in renal vascular resistance. Similar glomerular hemodynamic changes were observed in BK-B2 receptor-blocked newborn rabbits. These results indicate that BK does not play a significant role in the renal vascular changes of the hypoxemic-stressed newborn.
Mots-clé
Animals, Animals, Newborn, Anoxia, Bradykinin/pharmacology, Glomerular Filtration Rate/drug effects, Kidney/blood supply, Kidney/drug effects, Rabbits, Renal Circulation/drug effects
Pubmed
Web of science
Création de la notice
19/11/2007 13:47
Dernière modification de la notice
20/08/2019 15:53
Données d'usage