Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_8FEC91DF2193
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals.
Périodique
The British journal of psychiatry
ISSN
1472-1465 (Electronic)
ISSN-L
0007-1250
Statut éditorial
Publié
Date de publication
08/2017
Peer-reviewed
Oui
Volume
211
Numéro
2
Pages
70-76
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
BackgroundDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.AimsTo confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.MethodThe sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT.ResultsIn the replication cohorts, we observed a significant interaction between FTO, BMI and depression with fixed effects meta-analysis (β = 0.12, P = 2.7 × 10 <sup>-4</sup> ) and with the Han/Eskin random effects method (P = 1.4 × 10 <sup>-7</sup> ) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model (P = 6.9 × 10 <sup>-8</sup> ). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTOConclusionsThis meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression.
Mots-clé
Alleles, Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics, Body Mass Index, Case-Control Studies, Comorbidity, Depressive Disorder, Major/epidemiology, Depressive Disorder, Major/genetics, Genetic Predisposition to Disease/genetics, Humans, Obesity/epidemiology, Obesity/genetics, Polymorphism, Genetic/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/07/2017 18:22
Dernière modification de la notice
19/12/2023 8:23