Treatment of penile carcinoma: to cut or not to cut?

Détails

ID Serval
serval:BIB_8FB576FEC915
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Treatment of penile carcinoma: to cut or not to cut?
Périodique
International Journal of Radiation Oncology, Biology, Physics
Auteur(s)
Ozsahin M., Jichlinski P., Weber D.C., Azria D., Zimmermann M., Guillou L., Bulling S., Moeckli R., Mirimanoff R.O., Zouhair A.
ISSN
0360-3016
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
66
Numéro
3
Pages
674-679
Langue
anglais
Résumé
PURPOSE: The aim of this study was to assess the outcome in patients with penile cancer. METHODS AND MATERIALS: A total of 60 patients with penile carcinoma were included. Of the patients, 45 (n = 27) underwent surgery, and 51 underwent definitive (n = 29) or postoperative (n = 22) radiotherapy (RT). Median follow-up was 62 months. RESULTS: Median time to locoregional relapse was 14 months. Local failure was observed in 3 of 23 patients (13%) treated with surgery with or without postoperative RT vs. in 19 of 33 patients (56%) given organ-sparing treatment (p = 0.0008). Of 22 local failures, 16 (73%) were salvaged with surgery. Of the 33 patients treated with definitive RT (n = 29) and the 4 patients refusing RT after excisional biopsy, local control was obtained with organ preservation in 13 (39%). In the remaining 20, 4 patients with local failure underwent salvage conservatively, resulting in an ultimate penis preservation rate of 17 of 33 (52%) patients treated with definitive RT. The 5-year and 10-year probability of surviving with an intact penis was 43% and 26%, respectively. There was no survival difference between the patients treated with definitive RT and primary surgery (56% vs. 53%; p = 0.16). In multivariate analysis, independent factors influencing survival were N-classification and pathologic grade. Surgery was the only independent predictor for better local control. CONCLUSION: Based on our study findings, in patients with penile cancer, local control is superior with surgery. However, there is no difference in survival between patients treated with surgery and those treated with definitive RT, with 52% organ preservation.
Mots-clé
Adult, Aged, Aged, 80 and over, Analysis of Variance, Carcinoma, Squamous Cell, Chi-Square Distribution, Humans, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local, Penile Neoplasms, Penis, Prognosis, Retrospective Studies, Salvage Therapy
Pubmed
Web of science
Création de la notice
28/04/2008 10:35
Dernière modification de la notice
20/08/2019 14:53
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