The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal males
Détails
ID Serval
serval:BIB_8F9879B2AD0E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal males
Périodique
Human Genetics
ISSN
0340-6717 (Print)
Statut éditorial
Publié
Date de publication
11/2006
Volume
120
Numéro
4
Pages
447-59
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. A nonsense mutation in the gene was shown to be involved in a rare X-linked behavioural syndrome, which includes impaired impulse control, aggression and borderline mental retardation (Brunner syndrome). Several recent studies have shown the association of genetic variation of a VNTR in the gene promoter with various pathological behavioural traits. In the present study the association of MAOA genetic variation with a large set of quantitative behavioural traits in normal individuals has been examined. DNA samples from 421 unrelated males were genotyped for 14 SNPs and for the promoter VNTR at the MAOA locus. An additional 16 SNPs were genotyped at apparently neutral loci across the X chromosome to serve as a genomic control for possible false positive associations due to population structure. Behavioural traits were measured using the NEO psychometric questionnaire, which is based on a 5-axis model of personality, and consists of 30 different quantitative traits. There was a robust association of the A2 ("straightforwardness") facet with common allelic variants at the promoter VNTR. Most of the tested traits were not associated with the VNTR despite reasonable power, thus demonstrating that the VNTR influence on quantitative behavioural traits in normal males may be very specific. In contrast, several traits of the C ("conscientiousness") axis were associated with less common SNP-defined haplotypes. Hence, it appears that common genetic variation at the VNTR contributes to the behavioural attribute of "straightforwardness", while rare haplotypes defined by SNPs downstream of the transcription start site may contribute to "conscientiousness". This study is used to address the validation, interpretation and limitation of genetic association studies of quantitative behavioural traits.
Mots-clé
African Americans/genetics
Analysis of Variance
Asian Continental Ancestry Group/genetics
Base Sequence
*Behavior
European Continental Ancestry Group/genetics
Genetics, Behavioral
Genetics, Population
Genotype
Haplotypes
Hispanic Americans/genetics
Humans
Male
Minisatellite Repeats
Monoamine Oxidase/*genetics
Phenotype
Phylogeny
*Polymorphism, Single Nucleotide
Promoter Regions (Genetics)
Quantitative Trait Loci/*genetics
Variation (Genetics)
Pubmed
Web of science
Création de la notice
25/01/2008 17:17
Dernière modification de la notice
20/08/2019 15:53