Antihypertensive therapy and mobilization of renal functional reserve

Détails

ID Serval
serval:BIB_8F65F93582BE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Antihypertensive therapy and mobilization of renal functional reserve
Périodique
Clinical and Investigative Medicine
Auteur(s)
Burnier  M., Biollaz  J., Steinhauslin  F., Brouard  R., Waeber  B., Brunner  H. R.
ISSN
0147-958X (Print)
Statut éditorial
Publié
Date de publication
12/1991
Volume
14
Numéro
6
Pages
581-9
Notes
Journal Article
Review --- Old month value: Dec
Résumé
The normal kidney can increase its rate of glomerular filtration in response to an acute protein load. It has been suggested that this acute hyperfiltration represents a renal functional reserve (RFR). The RFR has also been proposed to reflect the chronic hyperfiltration found in diabetic patients and animal models of chronic renal failure. The physiologic role of the RFR is still unclear. On the one hand, the availability of an RFR may retard the progression towards end-stage renal failure. On the other hand, sustained hyperfiltration has been implicated as a potential deleterious factor in the progression of renal disease. Antihypertensive drugs used in the management of hypertensive patients with chronic renal disease modify both the systemic and the renal hemodynamics. Depending on their hemodynamic effects, they may thereby alter the ability to mobilize RFR. Today, it is still not clear whether an ideal compound should increase, decrease, or not affect RFR to preserve long-term renal function. Evaluation of the effects of various antihypertensive agents on RFR could become an important aspect of consideration in order to optimize both the control of blood pressure and the capacity of the therapy to prevent deterioration of renal function.
Mots-clé
Adrenergic beta-Antagonists/pharmacology/therapeutic use Angiotensin-Converting Enzyme Inhibitors/pharmacology/therapeutic use Animals Antihypertensive Agents/*pharmacology/therapeutic use Calcium Channel Blockers/pharmacology/therapeutic use Glomerular Filtration Rate Humans Hypertension/drug therapy/*physiopathology Kidney/drug effects/*physiopathology
Pubmed
Web of science
Création de la notice
25/01/2008 12:56
Dernière modification de la notice
20/08/2019 14:53
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