Intrathecal Administration of CXCL1 Enhances Potassium Currents in Microglial Cells.

Détails

ID Serval
serval:BIB_8F6213A6BF1B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Intrathecal Administration of CXCL1 Enhances Potassium Currents in Microglial Cells.
Périodique
Pharmacology
Auteur⸱e⸱s
Deftu A.F., Ristoiu V., Suter M.R.
ISSN
1423-0313 (Electronic)
ISSN-L
0031-7012
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
101
Numéro
5-6
Pages
262-268
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The functioning of microglial cells inside the central nervous system depends on their ion channels expression. Microglia are capable of synthesizing different cytokines and chemokines, including CXCL1, and responding to their action via specific receptors. In this study, we explore the effect of intrathecal injection of CXCL1 on potassium currents, expressed in CX3CR1-Green Fluorescent Protein labeled microglia in transgenic mice. The results showed that CXCL1 hyperpolarized the cells by enhancing inward rectifying potassium currents and increasing the membrane area, suggesting an activating effect on microglia.
Mots-clé
CXCL1, Microglia, Potassium currents
Pubmed
Web of science
Création de la notice
01/03/2018 20:47
Dernière modification de la notice
20/08/2019 14:53
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