Clinical Experience with Immune Monitoring for Cytomegalovirus in Solid-Organ Transplant Recipients.

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ID Serval
serval:BIB_8F58E6226C35
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Clinical Experience with Immune Monitoring for Cytomegalovirus in Solid-Organ Transplant Recipients.
Périodique
Current Infectious Disease Reports
Auteur⸱e⸱s
Manuel O.
ISSN
1523-3847 (Print)
ISSN-L
1523-3847
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
15
Numéro
6
Pages
491-496
Langue
anglais
Notes
Publication types: ARTICLE
Résumé
Novel strategies are needed to further reduce the burden of cytomegalovirus (CMV) disease in solid-organ transplant (SOT) recipients. Measurement of the specific cell-mediated immunity against CMV can identify the actual risk for the development of CMV disease in a given patient. Thus, immune monitoring is an attractive strategy for individualizing the management of CMV after transplantation. A growing number of observational studies on immune monitoring for CMV have been published over recent years, although there is a lack of data coming from interventional trials. In high-risk patients, measurement of CMV-specific T-cell responses appropriately stratifies the risk of CMV disease after discontinuation of antiviral prophylaxis. Immune monitoring may also help to identify patients followed by the preemptive approach at low risk for progression to CMV disease. Pretransplant assessment of cell-mediated immunity in seropositive patients may predict the development of posttransplant CMV infection. Overall, these studies indicate that the use of cell-mediated immunity assays has the potential to improve the management of CMV disease in SOT recipients.
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/08/2014 19:04
Dernière modification de la notice
14/02/2022 8:56
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