Plexiform hybrid granular cell tumor/perineurioma: a novel variant of benign peripheral nerve sheath tumor with divergent differentiation.

Détails

ID Serval
serval:BIB_8F30275B7CB0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Plexiform hybrid granular cell tumor/perineurioma: a novel variant of benign peripheral nerve sheath tumor with divergent differentiation.
Périodique
Pathology, research and practice
Auteur(s)
Matter A., Hewer E., Kappeler A., Fleischmann A., Vajtai I.
ISSN
1618-0631 (Electronic)
ISSN-L
0344-0338
Statut éditorial
Publié
Date de publication
15/05/2012
Peer-reviewed
Oui
Volume
208
Numéro
5
Pages
310-314
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
The descriptive term hybrid peripheral nerve sheath tumor refers to any neoplasm of the neurilemmal apparatus composed of more than one pathologically defined tumoral equivalent derived from its constituent cells. Within this uncommon nosological category, participation of granular cell tumor - a neoplasm of modified Schwann cells - has been reported only exceptionally. We describe a hitherto not documented variant composed of an organoid mixture of granular cell tumor and perineurioma with plexiform growth. A solitary subcutaneous nodule of 1.5 cm diameter was excised from the right ring finger of a 19-year-old female with no antecedents of neurofibromatosis or relevant trauma. Histology revealed a monotonous, yet cytologically dimorphic proliferation of classical granular cells intermingled with flattened, inconspicuous perineurial cells. Immunohistochemical double labeling detected expression of S100 protein in the former and of EMA and GLUT-1 in the latter. While the respective staining patterns for S100 protein and EMA or GLUT-1 tended to be mutually exclusive, a minority of cells exhibited transitional granular cell/perineurial immunophenotype. Electron microscopy permitted direct visualization of a plethora of lysosomes in the granular cell moiety, and of pinocytotic vesicles and tight junctions in perineurial cells. Intratumoral axons were not detected. Expanding intraneurally, the lesion showed discrete encapsulation by the local perineurium, and resulted in plexiform growth. The MIB-1 labeling index averaged 1%. We interpret our findings as supporting evidence for the dual cell lineage to have arisen through metaplasia, with the tumor's dynamics probably having been driven by the granular cell component.
Mots-clé
Biomarkers, Tumor/metabolism, Cell Proliferation, Female, Fingers, Glucose Transporter Type 1/metabolism, Granular Cell Tumor/metabolism, Granular Cell Tumor/pathology, Humans, Lysosomes/ultrastructure, Microscopy, Electron, Transmission, Mucin-1/metabolism, Nerve Sheath Neoplasms/metabolism, Nerve Sheath Neoplasms/pathology, S100 Proteins/metabolism, Soft Tissue Neoplasms/metabolism, Soft Tissue Neoplasms/pathology, Young Adult
Pubmed
Web of science
Création de la notice
31/08/2020 13:02
Dernière modification de la notice
10/11/2020 7:26
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