Infrequent transmission of HIV-1 drug-resistant variants.

Détails

ID Serval
serval:BIB_8E97B94E705E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Infrequent transmission of HIV-1 drug-resistant variants.
Périodique
Antiviral therapy
Auteur(s)
Yerly S., Jost S., Telenti A., Flepp M., Kaiser L., Chave J.P., Vernazza P., Battegay M., Furrer H., Chanzy B., Burgisser P., Rickenbach M., Gebhardt M., Bernard M.C., Perneger T., Hirschel B., Perrin L.
ISSN
1359-6535
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
9
Numéro
3
Pages
375-84
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
Transmission of drug-resistant variants is influenced by several factors, including the prevalence of drug resistance in the population of HIV-1-infected patients, HIV-1 RNA levels and transmission by recently infected patients. In order to evaluate the impact of these factors on the transmission of drug-resistant variants, we have defined the population of potential transmitters and compared their resistance profiles to those of newly infected patients. Sequencing of pol gene was performed in 220 recently infected patients and in 373 chronically infected patients with HIV-1 RNA >1000 copies/ml. Minimal and maximal drug-resistance profiles of potential transmitters were estimated by weighting resistance profiles of chronically infected patients with estimates of the Swiss HIV-1-infected population, the prevalence of exposure to antiviral drugs and the proportion of infections attributed to primary HIV infections. The drug-resistance prevalence in recently infected patients was 10.5% (one class drug resistance: 9.1%; two classes: 1.4%; three classes: 0%). Phylogenetic analysis revealed significant clustering for 30% of recent infections. The drug-resistance prevalence in chronically infected patients was 72.4% (one class: 29%; two classes: 27.6%; three classes: 15.8%). After adjustment, the risk of transmission relative to wild-type was reduced both for one class drug resistance (minimal and maximal estimates: odds ratio: 0.39, P<0.001; and odds ratio: 0.55, P=0.011, respectively), and for two to three class drug resistance (odds ratios: 0.05 and 0.07, respectively, P<0.001). Neither sexual behaviour nor HIV-1 RNA levels explained the low transmission of drug-resistant variants. These data suggest that drug-resistant variants and in particular multidrug-resistant variants have a substantially reduced transmission capacity.
Mots-clé
Adolescent, Adult, Aged, Anti-Retroviral Agents, Chronic Disease, Disease Transmission, Infectious, Drug Resistance, Viral, Female, Genes, pol, Genetic Variation, Genotype, HIV Infections, HIV-1, Humans, Male, Middle Aged, Odds Ratio, Phylogeny, Prevalence, RNA, Viral, Risk Factors, Switzerland
Pubmed
Web of science
Création de la notice
29/01/2008 9:52
Dernière modification de la notice
20/08/2019 15:52
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