Effect of total treatment of time on event-free survival in carcinoma of the cervix

Détails

ID Serval
serval:BIB_8E1EB0B15349
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of total treatment of time on event-free survival in carcinoma of the cervix
Périodique
Gynecologic Oncology
Auteur(s)
Delaloye  J. F., Coucke  P. A., Pampallona  S., De Grandi  P.
ISSN
0090-8258 (Print)
Statut éditorial
Publié
Date de publication
01/1996
Volume
60
Numéro
1
Pages
42-8
Notes
Clinical Trial
Journal Article --- Old month value: Jan
Résumé
The objective of this study was to analyze the effect of radiation therapy duration on event-free survival in patients with invasive carcinoma. Three hundred and sixty patients with FIGO stage IB-IIIB carcinoma of the cervix were treated with external radiation and brachytherapy as first line therapy. Median therapy duration was 45 days. Patients were classified according to whether they had rather long therapies, taking 60 days (the 75th percentile) as an arbitrary cutoff. Cumulative incidences of local recurrence, metastasis, and death were estimated. The 5-year event-free survival rate was 59 +/- 3% for the less than 60 days group and 42 +/- 7% for the more than 60 days group (P = 0.003). In terms of univariate hazard ratio (HR), the relative difference between the two groups corresponds to an increase in hazard of any of the three events considered more than the double (HR = 1.756, P = 0.003) for the longer therapy duration group. A multivariate analysis, which included selected prognostic factors, confirmed these results (HR = 1.76, P = 0.017). A short radiation therapy duration is a highly significant prognostic factor associated with longer event-free survival in carcinoma of the cervix.
Mots-clé
Adult Aged Aged, 80 and over Disease-Free Survival Female Humans Middle Aged Neoplasm Recurrence, Local/epidemiology Time Factors Uterine Cervical Neoplasms/*mortality/*radiotherapy
Pubmed
Web of science
Création de la notice
25/01/2008 15:42
Dernière modification de la notice
20/08/2019 14:52
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