Cystatin C as a marker of early changes of renal function in Fabry nephropathy.

Détails

ID Serval
serval:BIB_8DEE63EC54AF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cystatin C as a marker of early changes of renal function in Fabry nephropathy.
Périodique
Journal of Nephrology
Auteur(s)
Feriozzi S., Germain D.P., Di Vito R., Legrand A., Ricci R., Barbey F.
ISSN
1121-8428 (Print)
ISSN-L
1121-8428
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
20
Numéro
4
Pages
437-443
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND: A sensitive, feasible and reproducible marker for renal function is necessary to evaluate the clinical efficacy of enzyme replacement therapy (ERT) in Fabry nephropathy. Serum creatinine has some limitations and cystatin C has been proposed, in other nephropathies, as a useful marker of renal function. The use of cystatin C as a marker of glomerular filtration rate (GFR) was investigated in Fabry patients receiving ERT.
METHODS: Renal function was evaluated with serum creatinine, serum cystatin C and estimated GFR (through Modification of Diet in Renal Disease [MDRD], Cockcroft-Gault [C&G] and Hoek formulae) in 21 Fabry patients receiving ERT with agalsidase alfa for 3 years and in 13 Fabry patients receiving agalsidase alfa for 4 years.
RESULTS: During years of ERT while serum creatinine remained stable, cystatin C values showed a significant, increasing trend right from the first year of ERT.
CONCLUSIONS: In Fabry disease, cystatin C is a sensitive and reliable marker of renal function, and it should be taken into account when evaluating GFR trends during ERT.
Mots-clé
Adult, Aged, Biological Markers/blood, Creatinine/blood, Cystatin C, Cystatins/blood, Fabry Disease/complications, Fabry Disease/drug therapy, Female, Glomerular Filtration Rate, Humans, Kidney Diseases/diagnosis, Kidney Diseases/etiology, Male, Middle Aged, alpha-Galactosidase/therapeutic use
Pubmed
Web of science
Création de la notice
09/02/2012 16:43
Dernière modification de la notice
20/08/2019 14:51
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