Maternal consumption of piceatannol: A nutritional neuroprotective strategy against hypoxia-ischemia in rat neonates.

Détails

ID Serval
serval:BIB_8DAC3A84575D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Maternal consumption of piceatannol: A nutritional neuroprotective strategy against hypoxia-ischemia in rat neonates.
Périodique
Brain research
Auteur⸱e⸱s
Dumont U., Sanchez S., Olivier B., Chateil J.F., Pellerin L., Beauvieux M.C., Bouzier-Sore A.K., Roumes H.
ISSN
1872-6240 (Electronic)
ISSN-L
0006-8993
Statut éditorial
Publié
Date de publication
15/08/2019
Peer-reviewed
Oui
Volume
1717
Pages
86-94
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Hypoxia-ischemia (HI) remains a major cause of perinatal mortality and chronic disability in newborns worldwide (1-6 for 1000 births) with a high risk of future motor, behavioral and neurological deficits. Keeping newborns under moderate hypothermia is the unique therapeutic approach but is not sufficiently successful as nearly 50% of infants do not respond to it. In a 7-day post-natal rat model of HI, we used pregnant and breastfeeding female nutritional supplementation with piceatannol (PIC), a polyphenol naturally found in berries, grapes and passion fruit, as a neuroprotective strategy. Maternal supplementation led to neuroprotection against neonate brain damage and reversed their sensorimotor deficits as well as cognitive impairments. Neuroprotection of per os maternal supplementation with PIC is a preventive strategy to counteract brain damage in pups induced by HI. This nutritional approach could easily be adopted as a preventive strategy in humans.
Mots-clé
Behavior, Magnetic Resonance Imaging, Maternal supplementation, Neonatal hypoxia-ischemia, Neuroprotection, Piceatannol, Magnetic resonance imaging
Pubmed
Web of science
Création de la notice
28/04/2019 14:24
Dernière modification de la notice
21/08/2019 5:35
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