Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease

Détails

ID Serval
serval:BIB_8D72D7519BE7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease
Périodique
Arch Neurol
Auteur(s)
Ryvlin P., Broussolle E., Piollet H., Viallet F., Khalfallah Y., Chazot G.
ISSN
0003-9942 (Print)
ISSN-L
0003-9942
Statut éditorial
Publié
Date de publication
06/1995
Volume
52
Numéro
6
Pages
583-8
Langue
anglais
Notes
Ryvlin, P
Broussolle, E
Piollet, H
Viallet, F
Khalfallah, Y
Chazot, G
eng
Arch Neurol. 1995 Jun;52(6):583-8.
Résumé
OBJECTIVE: To determine the changes in basal ganglia iron content associated with various stages of idiopathic Parkinson's disease. DESIGN: Prospective magnetic resonance imaging study using a 2-T magnet. SETTING: Ambulatory care referral center. PATIENTS AND PARTICIPANTS: Forty-five patients suffering from levodopa-responsive Parkinson's disease and 45 age-matched controls. MAIN OUTCOME MEASURES: The T2 relaxation time calculated in various regions of the basal ganglia, the duration of Parkinson's disease, and the age of subjects. RESULTS: Patients with Parkinson's disease exhibited significantly decreased T2 relaxation time in the pars compacta of the substantia nigra compared with controls (P < .01), regardless of disease duration. Patients with a duration of illness above 10 years (n = 12) exhibited significantly increased T2 relaxation time in the anterior and posterior putamen (P < .005 and P < .01, respectively) and in the pallidum (P < .05) compared with age-matched controls. Putamental T2 relaxation time positively correlated with disease duration (P < .05). CONCLUSION: These results suggest that more complex brain iron changes than those previously reported are associated with idiopathic Parkinson's disease, including increased nigral iron content and decreased putamenal and pallidal iron concentration in patients with a duration of illness above 10 years.
Mots-clé
Adult, Aged, Basal Ganglia/metabolism/pathology, Female, Humans, Iron/*metabolism, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease/*diagnosis/*metabolism, Prospective Studies, Putamen/*metabolism/pathology
Pubmed
Création de la notice
29/11/2018 13:37
Dernière modification de la notice
20/08/2019 15:51
Données d'usage