Thermal adaptation rather than demographic history drives genetic structure inferred by copy number variants in a marine fish

Détails

ID Serval
serval:BIB_8D67B8B76E4B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Thermal adaptation rather than demographic history drives genetic structure inferred by copy number variants in a marine fish
Périodique
Molecular Ecology
Auteur⸱e⸱s
Cayuela H., Dorant Y., Mérot C., Laporte M., Normandeau E., Gagnon-Harvey S., Clément M., Sirois P., Bernatchez L.
ISSN
1365-294X (Electronic)
ISSN-L
0962-1083
Statut éditorial
Publié
Date de publication
10/02/2021
Peer-reviewed
Oui
Volume
30
Pages
1624-1641
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Résumé
Increasing evidence shows that structural variants represent an overlooked aspect of genetic variation with consequential evolutionary roles. Among those, copy number variants (CNVs), including duplicated genomic region and transposable elements (TEs) may contribute to local adaptation and/or reproductive isolation among divergent populations. Those mechanisms suppose that CNVs could be used to infer neutral and/or adaptive population genetic structure, whose study has been restricted to microsatellites, mtDNA, and AFLP markers in the past and more recently the use of SNPs. Taking advantage of recent developments allowing CNV analysis from RAD-seq data, we investigated how variation in fitness-related traits, local environmental conditions and demographic history are associated with CNVs, and how subsequent copy number variation drives population genetic structure in a marine fish, the capelin (Mallotus villosus). We collected 1538 DNA samples from 35 sampling sites in the north Atlantic Ocean and identified 6620 putative CNVs. We found associations between CNVs and the gonadosomatic index, suggesting that six duplicated regions could affect female fitness by modulating oocyte production. We also detected 105 CNV candidates associated with water temperature, among which 20% corresponded to genomic regions located within the sequence of protein-coding genes, suggesting local adaptation to cold water by means of gene sequence amplification. We also identified 175 CNVs associated with the divergence of three previously defined parapatric glacial lineages, of which 24% were located within protein-coding genes, making those loci potential candidates for reproductive isolation. Lastly, our analyses unveiled a hierarchical, complex CNV population structure determined by temperature and local geography, which was in stark contrast with that inferred based on SNPs in a previous study. Our findings underscore the complementarity of those two types of genomic variation in population genomics studies.
Mots-clé
copy number variants, fish, local adaptation, population genetic structure, reproductive isolation, structural variants, transposable elements
Pubmed
Financement(s)
Fonds national suisse / Projets / 31003A_182265
Création de la notice
15/02/2021 9:24
Dernière modification de la notice
01/06/2021 5:37
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