Sex differences in the hypothalamo-pituitary-adrenal axis response to inflammatory and neuroendocrine stressors. Evidence for a pituitary defect in the autoimmune disease-susceptible female Lewis rat

Détails

ID Serval
serval:BIB_8D45D91957A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sex differences in the hypothalamo-pituitary-adrenal axis response to inflammatory and neuroendocrine stressors. Evidence for a pituitary defect in the autoimmune disease-susceptible female Lewis rat
Périodique
Neuroendocrinology
Auteur⸱e⸱s
Spinedi  E., Salas  M., Chisari  A., Perone  M., Carino  M., Gaillard  R. C.
ISSN
0028-3835 (Print)
Statut éditorial
Publié
Date de publication
12/1994
Volume
60
Numéro
6
Pages
609-17
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
Susceptibility to inflammatory disease in infantile Lewis (LEW/N) female rats seems to be related to their impaired hypothalamo-pituitary-adrenal (HPA) axis response to different inflammatory stimuli, while the relative resistance to this type of disease in Fischer (F344/N) female rats is apparently due to their potent HPA axis response to the same stimuli. In the present study, we attempted to elucidate whether there is an impairment in the HPA axis response in the juvenile female LEW/N rat to inflammatory and noninflammatory stimuli, and also to determine whether the endogenous sex-steroid environment influences the HPA axis function in both strains of rats. For these purposes, juvenile F344/N and LEW/N rats of both sexes were submitted to different treatments: (a) inhalation of normal atmosphere or ether vapors for 1 min (Ether); (b) i.p. injection of vehicle alone or containing CRH (0.5 microgram/rat), arginine vasopressin (AVP; 5 micrograms/rat, angiotensin II (AII; 5 micrograms/rat), insulin (INS; 0.3 IU/rat), bacterial lipopolysaccharide (LPS; 100 micrograms/rat) or snake venom (SV; 100 micrograms/rat). Rats were then killed at different time intervals (in min) after treatments: 20 for Ether, AVP and CRH, 30 for AII, 45 for INS, 60 for SV and 120 for LPS.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Adrenocorticotropic Hormone/blood/*secretion Angiotensin II/pharmacology Animals Arginine Vasopressin/metabolism/pharmacology Blood Glucose/analysis Corticotropin-Releasing Hormone/metabolism/*pharmacology Ether, Ethyl/pharmacology Female Hypothalamo-Hypophyseal System/drug effects/*physiology Inflammation Mediators/administration & dosage/*pharmacology Insulin/pharmacology Lipopolysaccharides/pharmacology Male Pituitary-Adrenal System/drug effects/*physiology Rats Rats, Inbred F344 Rats, Inbred Lew *Sex Characteristics Snake Venoms/pharmacology
Pubmed
Web of science
Création de la notice
15/02/2008 16:58
Dernière modification de la notice
20/08/2019 14:51
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