ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting.

Détails

ID Serval
serval:BIB_8CE2A4143A80
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting.
Périodique
Journal of Thoracic Oncology
Auteur(s)
Marx A., Ströbel P., Badve S.S., Chalabreysse L., Chan J.K., Chen G., de Leval L., Detterbeck F., Girard N., Huang J., Kurrer M.O., Lauriola L., Marino M., Matsuno Y., Molina T.J., Mukai K., Nicholson A.G., Nonaka D., Rieker R., Rosai J., Ruffini E., Travis W.D.
ISSN
1556-1380 (Electronic)
ISSN-L
1556-0864
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
9
Numéro
5
Pages
596-611
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish PDF: Special article
Résumé
INTRODUCTION: The 2004 version of the World Health Organization classification subdivides thymic epithelial tumors into A, AB, B1, B2, and B3 (and rare other) thymomas and thymic carcinomas (TC). Due to a morphological continuum between some thymoma subtypes and some morphological overlap between thymomas and TC, a variable proportion of cases may pose problems in classification, contributing to the poor interobserver reproducibility in some studies.
METHODS: To overcome this problem, hematoxylin-eosin-stained and immunohistochemically processed sections of prototypic, "borderland," and "combined" thymomas and TC (n = 72) were studied by 18 pathologists at an international consensus slide workshop supported by the International Thymic Malignancy Interest Group.
RESULTS: Consensus was achieved on refined criteria for decision making at the A/AB borderland, the distinction between B1, B2, and B3 thymomas and the separation of B3 thymomas from TCs. "Atypical type A thymoma" is tentatively proposed as a new type A thymoma variant. New reporting strategies for tumors with more than one histological pattern are proposed.
CONCLUSION: These guidelines can set the stage for reproducibility studies and the design of a clinically meaningful grading system for thymic epithelial tumors.
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/05/2014 17:55
Dernière modification de la notice
20/08/2019 15:51
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