Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo.

Détails

ID Serval
serval:BIB_8CD458907FAA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo.
Périodique
Immunity
Auteur(s)
Phalipon A., Cardona A., Kraehenbuhl J.P., Edelman L., Sansonetti P.J., Corthésy B.
ISSN
1074-7613[print], 1074-7613[linking]
Statut éditorial
Publié
Date de publication
2002
Volume
17
Numéro
1
Pages
107-115
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
Secretory immunoglobulin (Ig) A (SIgA) is essential in protecting mucosal surfaces. It is composed of at least two monomeric IgA molecules, covalently linked through the J chain, and secretory component (SC). We show here that a dimeric/polymeric IgA (IgA(d/p)) is more efficient when bound to SC in protecting mice against bacterial infection of the respiratory tract. We demonstrate that SC ensures, through its carbohydrate residues, the appropriate tissue localization of SIgA by anchoring the antibody to mucus lining the epithelial surface. This in turn impacts the localization and the subsequent clearance of bacteria. Thus, SC is directly involved in the SIgA function in vivo. Therefore, binding of IgA(d/p) to SC during the course of SIgA-mediated mucosal response constitutes a crucial step in achieving efficient protection of the epithelial barrier by immune exclusion.
Mots-clé
Animals, Dysentery, Bacillary/immunology, Dysentery, Bacillary/microbiology, Glycosylation, Immunity, Mucosal, Immunoglobulin A, Secretory/analysis, Immunoglobulin A, Secretory/immunology, Lung/immunology, Lung/pathology, Mice, Nasal Cavity/immunology, Respiratory Tract Infections/immunology, Respiratory Tract Infections/microbiology, Secretory Component/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 15:53
Dernière modification de la notice
20/08/2019 15:51
Données d'usage