The advantages of angiotensin II antagonism

Détails

ID Serval
serval:BIB_8CC1E312BB63
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The advantages of angiotensin II antagonism
Périodique
Journal of Hypertension. Supplement
Auteur(s)
Burnier  M., Waeber  B., Brunner  H. R.
ISSN
0952-1178 (Print)
Statut éditorial
Publié
Date de publication
07/1994
Volume
12
Numéro
2
Pages
S7-15
Notes
Comparative Study
Journal Article
Review --- Old month value: Jul
Résumé
New approaches to renin-angiotensin blockade: The successful use of angiotensin converting enzyme (ACE) inhibitors in the treatment of hypertension and congestive heart failure has generated a great deal of research interest in developing new pharmacological approaches to block the renin-angiotensin system. In recent years, several new non-peptide angiotensin II antagonists have been synthesized and some of them are available for experimental and/or clinical investigations. Now that experience with the antagonist losartan is accumulating, it is important to compare the effects, the efficacy and the side effects of this agent with those of ACE inhibitors. Effects of losartan compared with ACE inhibitors: So far, ACE inhibitors and the angiotensin II antagonist losartan appear to have similar systemic and regional hemodynamic effects. The impact of ACE inhibition and angiotensin blockade on the various components of the renin-angiotensin system is also comparable except for a marked increase in plasma angiotensin II levels during angiotensin II blockade. This increase in circulating angiotensin II might theoretically lead to an excessive stimulation of the AT2 receptor subtype, but since the function of this receptor is not known it is impossible to evaluate the implications of this reactive rise. Renal effects of losartan: The renal effects of angiotensin II antagonists are also very similar to those of ACE inhibitors. However, a marked increase in uric acid excretion has been observed with the administration of losartan. This uricosuric effect of losartan might represent a clinical advantage unless a state of urinary supersaturation of undissociated uric acid is achieved.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Angiotensin II/*antagonists & inhibitors Angiotensin-Converting Enzyme Inhibitors/pharmacology Animals Antihypertensive Agents/*pharmacology Biphenyl Compounds/*pharmacology Enalapril/pharmacology Hemodynamic Processes/drug effects Humans Imidazoles/*pharmacology Kidney/drug effects Losartan Receptors, Angiotensin/antagonists & inhibitors Renin-Angiotensin System/drug effects Tetrazoles/*pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 12:56
Dernière modification de la notice
20/08/2019 14:51
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