The implications of alternative splicing in the ENCODE protein complement.

Détails

ID Serval
serval:BIB_8C90D5BA1A30
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The implications of alternative splicing in the ENCODE protein complement.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Tress M.L., Martelli P.L., Frankish A., Reeves G.A., Wesselink J.J., Yeats C., Olason P.I., Albrecht M., Hegyi H., Giorgetti A., Raimondo D., Lagarde J., Laskowski R.A., López G., Sadowski M.I., Watson J.D., Fariselli P., Rossi I., Nagy A., Kai W., Størling Z., Orsini M., Assenov Y., Blankenburg H., Huthmacher C., Ramírez F., Schlicker A., Denoeud F., Jones P., Kerrien S., Orchard S., Antonarakis S.E., Reymond A., Birney E., Brunak S., Casadio R., Guigo R., Harrow J., Hermjakob H., Jones D.T., Lengauer T., Orengo C.A., Patthy L., Thornton J.M., Tramontano A., Valencia A.
ISSN
0027-8424[print], 0027-8424[linking]
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
104
Numéro
13
Pages
5495-5500
Langue
anglais
Résumé
Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological function of the expressed protein and even to create new protein functions. Alternative splicing has been suggested as one explanation for the discrepancy between the number of human genes and functional complexity. Here, we carry out a detailed study of the alternatively spliced gene products annotated in the ENCODE pilot project. We find that alternative splicing in human genes is more frequent than has commonly been suggested, and we demonstrate that many of the potential alternative gene products will have markedly different structure and function from their constitutively spliced counterparts. For the vast majority of these alternative isoforms, little evidence exists to suggest they have a role as functional proteins, and it seems unlikely that the spectrum of conventional enzymatic or structural functions can be substantially extended through alternative splicing.
Mots-clé
Alternative Splicing, Databases, Genetic, Gene Expression Regulation, Genome, Human, Humans, Internet, Models, Molecular, Protein Conformation, Protein Isoforms, Protein Sorting Signals, Protein Structure, Tertiary, Proteins/chemistry, RNA Precursors, RNA Splicing
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:52
Dernière modification de la notice
20/08/2019 15:50
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