Traitement de l'hypertension artérielle et interactions médicamenteuses [Antihypertensive therapy and drug-drug interactions]

Détails

Ressource 1Télécharger: RMS_IA-antiHTA.pdf (148.02 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_8C7F0B579BB6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Traitement de l'hypertension artérielle et interactions médicamenteuses [Antihypertensive therapy and drug-drug interactions]
Périodique
Revue medicale suisse
Auteur⸱e⸱s
Girardin F., Pechère-Bertschi A.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
14/09/2005
Peer-reviewed
Oui
Volume
1
Numéro
32
Pages
2099-2100,2102-2104
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Résumé
Adverse drug reactions (ADR) have increasing clinical implications and are a permanent challenge for general practitioners. Data suggest that ADR cause 3 to 18% of all hospital admissions with potentially serious consequences. Polymedication, female sex, multiple pathologies with age-related changes are predisposing factors. Antihypertensive drugs with a low bioavailability, a high protein binding capacity and specific elimination pathways are particularly prone to pharmacokinetic interactions. ACE-inhibitors, atenolol, moxonidine and diuretics have few pharmacokinetic interactions. Calcium channel blockers and beta-blockers are associated with an increased risk of pharmacokinetic drug-drug interactions. Diltiazem and verapamil are particularly prone to interactions, as they strongly inhibit the elimination of drugs undergoing the CYP3A4 and P-glycoprotein pathways.
Mots-clé
Antihypertensive Agents/adverse effects, Antihypertensive Agents/metabolism, Cytochrome P-450 Enzyme System/metabolism, Drug Interactions, Humans
Pubmed
Création de la notice
10/02/2021 11:32
Dernière modification de la notice
03/05/2023 8:33
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