Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm ?

Détails

ID Serval
serval:BIB_8C69091ABADA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Morphological substrates of cognitive decline in nonagenarians and centenarians: a new paradigm ?
Périodique
Journal of the Neurological Sciences
Auteur(s)
Imhof Anouk, Kövari Enikö, Gunten Armin von, Gold Gabriel, Rivara Claire Bénédicte, Herrmann François R., Hof Patrick R., Bouras Constantin, Giannakopoulos Panteleimon
ISSN
0022-510X
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
257
Numéro
1/2
Pages
72-79
Langue
anglais
Notes
Mention de responsabiblité : SAPHIRID:64350
Résumé
Brain aging is characterized by the formation of neurofibrillary tangles (NFT) and senile plaques (SP) in both cognitively intact individuals and patients with Alzheimer's disease (AD). The ubiquitous presence of these lesions and the steady increase of the prevalence of dementia up to 85 years have strongly supported a continuum between normal brain aging and AD. In this context, the study of nonagenarians and centenarians could provide key informations about the characteristics of extreme aging. We provide here a detailed review of currently available neuropathological data in very old individuals and critically discuss the patterns of NFT, SP and neuronal loss distribution as a function of age. In younger cohorts, NFTs are usually restricted to hippocampal formation, whereas clinical signs of dementia appear when temporal neocortex is involved. SPs would not be a specific marker of cognitive impairment as no correlation was found between their quantitative distribution and AD severity. The low rate of AD lesions even in severe AD as well as the weakness of clinicopathological correlations reported in the oldest-old indicate that AD pathology is not a mandatory phenomenon of increasing chronological age. Our recent stereological observations of hippocampal microvasculature in oldest-old cases challenge the traditional lesional model by revealing that mean capillary diameters is an important structural determinant of cognition in this age group.
Pubmed
Web of science
Création de la notice
10/03/2008 11:04
Dernière modification de la notice
20/08/2019 14:50
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