Identification of prognostic molecular features in the reactive stroma of human breast and prostate cancer.

Détails

Ressource 1Télécharger: BIB_8C3D90637CE6.P001.pdf (3900.58 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_8C3D90637CE6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Identification of prognostic molecular features in the reactive stroma of human breast and prostate cancer.
Périodique
Plos One
Auteur⸱e⸱s
Planche A., Bacac M., Provero P., Fusco C., Delorenzi M., Stehle J.C., Stamenkovic I.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2011
Volume
6
Numéro
5
Pages
e18640
Langue
anglais
Résumé
Primary tumor growth induces host tissue responses that are believed to support and promote tumor progression. Identification of the molecular characteristics of the tumor microenvironment and elucidation of its crosstalk with tumor cells may therefore be crucial for improving our understanding of the processes implicated in cancer progression, identifying potential therapeutic targets, and uncovering stromal gene expression signatures that may predict clinical outcome. A key issue to resolve, therefore, is whether the stromal response to tumor growth is largely a generic phenomenon, irrespective of the tumor type or whether the response reflects tumor-specific properties. To address similarity or distinction of stromal gene expression changes during cancer progression, oligonucleotide-based Affymetrix microarray technology was used to compare the transcriptomes of laser-microdissected stromal cells derived from invasive human breast and prostate carcinoma. Invasive breast and prostate cancer-associated stroma was observed to display distinct transcriptomes, with a limited number of shared genes. Interestingly, both breast and prostate tumor-specific dysregulated stromal genes were observed to cluster breast and prostate cancer patients, respectively, into two distinct groups with statistically different clinical outcomes. By contrast, a gene signature that was common to the reactive stroma of both tumor types did not have survival predictive value. Univariate Cox analysis identified genes whose expression level was most strongly associated with patient survival. Taken together, these observations suggest that the tumor microenvironment displays distinct features according to the tumor type that provides survival-predictive value.
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/09/2011 13:42
Dernière modification de la notice
20/08/2019 14:50
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