RISK FACTORS FOR RECURRENCES OF CENTRAL SEROUS CHORIORETINOPATHY.

Détails

ID Serval
serval:BIB_8C2A6316A47C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
RISK FACTORS FOR RECURRENCES OF CENTRAL SEROUS CHORIORETINOPATHY.
Périodique
Retina
Auteur(s)
Matet A., Daruich A., Zola M., Behar-Cohen F.
ISSN
1539-2864 (Electronic)
ISSN-L
0275-004X
Statut éditorial
Publié
Date de publication
07/2018
Peer-reviewed
Oui
Volume
38
Numéro
7
Pages
1403-1414
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study
Publication Status: ppublish
Résumé
To describe recurrence patterns and investigate candidate risk factors for recurrences of central serous chorioretinopathy.
In 46 patients with acute central serous chorioretinopathy and follow-up >12 months after first episode resolution, parameters influencing recurrences were retrospectively evaluated using a frailty Cox proportional hazard survival model. Covariates included baseline systemic findings: age, gender, corticosteroid use, stress, shift work, sleep disorder, depression, allergy, cardiovascular risk; baseline optical coherence tomography findings: subfoveal choroidal thickness, pigment epithelial detachment pattern (regular/bump/irregular), number of subretinal hyperreflective foci at leakage site; baseline angiographic findings: fluorescein leakage intensity (intense/moderate/subtle/absent), hyperpermeability pattern on indocyanine-green angiography (focal/multifocal); and episode-related findings: duration and treatment of previous episode.
Twenty of 46 subjects (43%) presented ≥1 recurrences during a mean follow-up of 29.9 ± 9.5 months (range, 15-54 months). Follow-up duration did not differ between cases with or without recurrences (P = 0.3). Worse final visual acuity levels (logarithm of the minimal angle of resolution) were associated with a higher number of episodes during follow-up (P = 0.032, r = 0.28). In a univariate analysis, higher subfoveal choroidal thickness (P = 0.021), nonintense fluorescein leakage (= moderate/subtle/absent, P = 0.033), multiple subretinal hyperreflective foci (P = 0.026), and shift work (P < 0.0001) were significantly associated with recurrences, with a near-significant influence of irregular pigment epithelial detachment (P = 0.093). In a multivariate analysis, higher subfoveal choroidal thickness (P = 0.007), nonintense fluorescein leakage (P = 0.003) and shift work (P < 0.0001) remained significant and independent risk factors for recurrences.
Multiple factors influence the risk of central serous chorioretinopathy recurrence. These findings may contribute to identify patients at higher risk, who could benefit from earlier or more intensive treatment.
Mots-clé
Acute Disease, Adult, Central Serous Chorioretinopathy/diagnosis, Central Serous Chorioretinopathy/epidemiology, Choroid/pathology, Female, Fluorescein Angiography, Follow-Up Studies, Fundus Oculi, Humans, Incidence, Male, Middle Aged, Recurrence, Retina/pathology, Retrospective Studies, Risk Assessment, Risk Factors, Switzerland/epidemiology, Time Factors, Tomography, Optical Coherence, Visual Acuity
Pubmed
Web of science
Création de la notice
19/06/2017 8:37
Dernière modification de la notice
20/08/2019 14:50
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