Change in Trabecular Bone Score (TBS) With Antiresorptive Therapy Does Not Predict Fracture in Women: The Manitoba BMD Cohort.

Détails

ID Serval
serval:BIB_8C28C14AF8F6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Change in Trabecular Bone Score (TBS) With Antiresorptive Therapy Does Not Predict Fracture in Women: The Manitoba BMD Cohort.
Périodique
Journal of bone and mineral research
Auteur(s)
Leslie W.D., Majumdar S.R., Morin S.N., Hans D., Lix L.M.
ISSN
1523-4681 (Electronic)
ISSN-L
0884-0431
Statut éditorial
Publié
Date de publication
03/2017
Peer-reviewed
Oui
Volume
32
Numéro
3
Pages
618-623
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Bone mineral density (BMD) and trabecular bone score (TBS), along with additional clinical risk factors, can be used to identify individuals at high fracture risk. Whether change in TBS in untreated or treated women independently affects fracture risk is unclear. Using the Manitoba (Canada) DXA Registry containing all BMD results for the population we identified 9044 women age ≥40 years with two consecutive DXA scans and who were not receiving osteoporosis treatment at baseline (baseline mean age 62 ± 10 years). We examined BMD and TBS change, osteoporosis treatment, and incident major osteoporotic fractures (MOFs) for each individual. Over a mean of 7.7 years follow-up, 770 women developed an incident MOF. During the interval between the two DXA scans (mean, 4.1 years), 5083 women initiated osteoporosis treatment (bisphosphonate use 80%) whereas 3961 women did not receive any osteoporosis treatment. Larger gains in both BMD and TBS were seen in women with greater adherence to osteoporosis medication (p for trend <0.001), and the magnitude of the increase was consistently greater for BMD than for TBS. Among treated women there was greater antifracture effect for each SD increase in total hip BMD change (fracture decrease 20%; 95% CI, 13% to 26%; p < 0.001), femoral neck BMD change (19%; 95% CI, 12% to 26%; p < 0.001), and lumbar spine BMD change (9%; 95% CI, 0% to 17%; p = 0.049). In contrast, change in TBS did not predict fractures in women who initiated osteoporosis treatment (p = 0.10). Among untreated women neither change in BMD or TBS predicted fractures. We conclude that, unlike antiresorptive treatment-related changes in BMD, change in lumbar spine TBS is not a useful indicator of fracture risk irrespective of osteoporosis treatment. © 2016 American Society for Bone and Mineral Research.

Mots-clé
Bone Density/drug effects, Bone Density Conservation Agents/pharmacology, Bone Density Conservation Agents/therapeutic use, Bone Resorption/drug therapy, Bone Resorption/epidemiology, Cancellous Bone/drug effects, Cancellous Bone/pathology, Cohort Studies, Female, Fractures, Bone/diagnosis, Fractures, Bone/epidemiology, Fractures, Bone/physiopathology, Humans, Incidence, Lumbar Vertebrae/physiopathology, Manitoba/epidemiology, Middle Aged, DXA, FRACTURE RISK ASSESSMENT, OSTEOPOROSIS, OTHER ANALYSIS/QUANTITATION OF BONE
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/02/2017 15:53
Dernière modification de la notice
20/08/2019 14:50
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