Concentration-dependent half-lives of polychlorinated biphenyl in sera from an occupational cohort

Détails

Ressource 1Télécharger: BIB_8BDC5DF0E70D.P001.pdf (109.94 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_8BDC5DF0E70D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Concentration-dependent half-lives of polychlorinated biphenyl in sera from an occupational cohort
Périodique
Chemosphere
Auteur⸱e⸱s
Hopf Nancy B., Ruder Avima M., Waters Martha A., Succop Paul
ISSN
1879-1298 (Electronic)
ISSN-L
0045-6535
Statut éditorial
Publié
Date de publication
04/2013
Peer-reviewed
Oui
Volume
91
Numéro
2
Pages
172-178
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Polychlorinated biphenyls (PCBs) are carcinogenic. Estimating PCB half-life in the body based on levels in sera from exposed workers is complicated by the fact that occupational exposure to PCBs was to commercial PCB products (such as Aroclors 1242 and 1254) comprised of varying mixtures of PCB congeners. Half-lives were estimated using sera donated by 191 capacitor manufacturing plant workers in 1976 during PCB use (1946-1977), and post-exposure (1979, 1983, and 1988). Our aims were to: (1) determine the role of covariates such as gender on the half-life estimates, and (2) compare our results with other published half-life estimates based on exposed workers. All serum PCB levels were adjusted for PCB background levels. A linear spline model with a single knot was used to estimate two separate linear equations for the first two serum draws (Equation A) and the latter two (Equation B). Equation A gave half-life estimates of 1.74 years and 6.01 years for Aroclor 1242 and Aroclor 1254, respectively. Estimates were 21.83 years for Aroclor 1242 and 133.33 years for Aroclor 1254 using Equation B. High initial body burden was associated with rapid PCB elimination in workers at or shortly after the time they were occupationally exposed and slowed down considerably when the dose reached background PCB levels. These concentration-dependent half-life estimates had a transition point of 138.57 and 34.78 ppb for Aroclor 1242 and 1254, respectively. This result will help in understanding the toxicological and epidemiological impact of exposure to PCBs in humans.

Mots-clé
Environmental Pollutants/metabolism, Female, Half-Life, Humans, Male, Occupational Exposure/statistics & numerical data, Polychlorinated Biphenyls/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2013 12:52
Dernière modification de la notice
20/08/2019 15:50
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