Risk factors for survival after lung metastasectomy in colorectal cancer patients: a systematic review and meta-analysis.

Détails

ID Serval
serval:BIB_8B4252EDB8AB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Risk factors for survival after lung metastasectomy in colorectal cancer patients: a systematic review and meta-analysis.
Périodique
Annals of Surgical Oncology
Auteur(s)
Gonzalez M., Poncet A., Combescure C., Robert J., Ris H.B., Gervaz P.
ISSN
1534-4681 (Electronic)
ISSN-L
1068-9265
Statut éditorial
Publié
Date de publication
2013
Volume
20
Numéro
2
Pages
572-579
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublishty PDF type: Systematic Review and Meta-Analysis
Résumé
BACKGROUND: Resection of lung metastases (LM) from colorectal cancer (CRC) is increasingly performed with a curative intent. It is currently not possible to identify those CRC patients who may benefit the most from this surgical strategy. The aim of this study was to perform a systematic review of risk factors for survival after lung metastasectomy for CRC.
METHODS: We performed a meta-analysis of series published between 2000 and 2011, which focused on surgical management of LM from CRC and included more than 40 patients each. Pooled hazard ratios (HR) were calculated by using random effects model for parameters considered as potential prognostic factors.
RESULTS: Twenty-five studies including a total of 2925 patients were considered in this analysis. Four parameters were associated with poor survival: (1) a short disease-free interval between primary tumor resection and development of LM (HR 1.59, 95 % confidence interval [CI] 1.27-1.98); (2) multiple LM (HR 2.04, 95 % CI 1.72-2.41); (3) positive hilar and/or mediastinal lymph nodes (HR 1.65, 95 % CI 1.35-2.02); and (4) elevated prethoracotomy carcinoembryonic antigen (HR 1.91, 95 % CI 1.57-2.32). By comparison, a history of resected liver metastases (HR 1.22, 95 % CI 0.91-1.64) did not achieve statistical significance.
CONCLUSIONS: Clinical variables associated with prolonged survival after surgery for LM in CRC patients include prolonged disease-free interval between primary tumor and metastatic spread, normal prethoracotomy carcinoembryonic antigen, absence of thoracic node involvement, and a single pulmonary lesion.
Pubmed
Web of science
Création de la notice
01/03/2013 18:55
Dernière modification de la notice
20/08/2019 15:49
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