Health-related quality of life in survivors of childhood cancer: the role of chronic health problems.

Détails

ID Serval
serval:BIB_8B212006E0E6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Health-related quality of life in survivors of childhood cancer: the role of chronic health problems.
Périodique
Journal of Cancer Survivorship : Research and Practice
Auteur(s)
Rueegg C.S., Gianinazzi M.E., Rischewski J., Beck Popovic M., von der Weid N.X., Michel G., Kuehni C.E.
ISSN
1932-2267 (Electronic)
ISSN-L
1932-2259
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
7
Numéro
4
Pages
511-522
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
INTRODUCTION: The influence of specific health problems on health-related quality of life (HRQoL) in childhood cancer survivors is unknown. We compared HRQoL between survivors of childhood cancer and their siblings, determined factors associated with HRQoL, and investigated the influence of chronic health problems on HRQoL.
METHODS: Within the Swiss Childhood Cancer Survivor Study, we sent a questionnaire to all survivors (≥16 years) registered in the Swiss Childhood Cancer Registry, who survived >5 years and were diagnosed 1976-2005 aged <16 years. Siblings received similar questionnaires. We assessed HRQoL using Short Form-36 (SF-36). Health problems from a standard questionnaire were classified into overweight, vision impairment, hearing, memory, digestive, musculoskeletal or neurological, and thyroid problems.
RESULTS: The sample included 1,593 survivors and 695 siblings. Survivors scored significantly lower than siblings in physical function, role limitation, general health, and the Physical Component Summary (PCS). Lower score in PCS was associated with a diagnosis of central nervous system tumor, retinoblastoma or bone tumor, having had surgery, cranio-spinal irradiation, or bone marrow transplantation. Lower score in Mental Component Summary was associated with older age. All health problems decreased HRQoL in all scales. Most affected were survivors reporting memory problems and musculoskeletal or neurological problems. Health problems had the biggest impact on physical functioning, general health, and energy and vitality.
CONCLUSIONS: In this study, we showed the negative impact of specific chronic health problems on survivors' HRQoL.
IMPLICATIONS FOR CANCER SURVIVORS: Therapeutic preventive measures, risk-targeted follow-up, and interventions might help decrease health problems and, consequently, improve survivors' quality of life.
Pubmed
Web of science
Création de la notice
03/01/2014 10:33
Dernière modification de la notice
20/08/2019 15:49
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