Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.

Détails

ID Serval
serval:BIB_8AF1F1467937
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation.
Périodique
FEBS Letters
Auteur⸱e⸱s
Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J.
ISSN
0014-5793[print], 0014-5793[linking]
Statut éditorial
Publié
Date de publication
2001
Volume
496
Numéro
2-3
Pages
121-127
Langue
anglais
Résumé
Bcl10, a caspase recruitment domain (CARD)-containing protein identified from a breakpoint in mucosa-associated lymphoid tissue (MALT) B lymphomas, is essential for antigen-receptor-mediated nuclear factor kappaB (NF-kappaB) activation in lymphocytes. We have identified a novel CARD-containing protein and interaction partner of Bcl10, named Carma1. Carma1 is predominantly expressed in lymphocytes and represents a new member of the membrane-associated guanylate kinase family. Carma1 binds Bcl10 via its CARD motif and induces translocation of Bcl10 from the cytoplasm into perinuclear structures. Moreover, expression of Carma1 induces phosphorylation of Bcl10 and activation of the transcription factor NF-kappaB. We propose that Carma1 is a crucial component of a novel Bcl10-dependent signaling pathway in T-cells that leads to the activation of NF-kappaB.
Mots-clé
Amino Acid Sequence, Blotting, Northern, Cell Nucleus/metabolism, Cloning, Molecular, Cytoplasm/metabolism, DNA, Complementary/metabolism, Enzyme Activation, Expressed Sequence Tags, Guanylate Kinase, Hela Cells, Humans, Lymphoma/metabolism, Microscopy, Confocal, Microscopy, Fluorescence, Models, Biological, Molecular Sequence Data, NF-kappa B/metabolism, Nucleoside-Phosphate Kinase/chemistry, Nucleoside-Phosphate Kinase/metabolism, Phosphorylation, Precipitin Tests, Protein Binding, Protein Structure, Tertiary, Sequence Homology, Amino Acid, Signal Transduction, T-Lymphocytes/metabolism, Tissue Distribution, Transfection, Up-Regulation
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
20/08/2019 15:49
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