Postmortem IgE determination in coronary artery disease.
Détails
ID Serval
serval:BIB_8AD8208014ED
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Postmortem IgE determination in coronary artery disease.
Périodique
Journal of forensic and legal medicine
ISSN
1878-7487 (Electronic)
ISSN-L
1752-928X
Statut éditorial
Publié
Date de publication
02/2019
Peer-reviewed
Oui
Volume
62
Pages
1-6
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Allergic, IgE-mediated inflammation is thought to play a role in atherogenesis and atherosclerotic disease progression. In this study, total IgE and mast cell tryptase were measured in a series of forensic autopsy cases including non-allergic cardiac deaths (14 cases with minimal or no coronary atherosclerosis, 14 cases with significant coronary artery atherosclerosis without acute coronary thrombosis, and 14 cases with significant coronary artery atherosclerosis and acute coronary thrombosis or myocardial infarction) and non-allergic non-cardiac deaths (21 cases with death due to hanging and 21 cases with death due to intracranial gunshot wounds), in order to correlate laboratory results with morphological findings and compare them to conclusions reported in the clinical setting. In cardiac death cases, postmortem serum total IgE levels were increased in 7 out of 42 cases and mast cell tryptase levels were increased in 3 out of 42 cases. In non-cardiac death cases, postmortem serum total IgE levels were not increased in 39 out of 42 cases and mast cell tryptase levels were not increased in any of these cases. These preliminary findings seem to indicate that a portion of coronary deaths characterized by coronary artery atherosclerosis of various severities are also characterized by increased total IgE and mast cell tryptase levels, thus corroborating the data previously reported in both clinical and forensic literature on this topic as well as the necessity of combining morphological investigations focusing on the heart and coronary arteries with biochemical analyses.
Mots-clé
Adult, Case-Control Studies, Coronary Artery Disease/blood, Coronary Thrombosis/blood, Female, Humans, Immunoglobulin E/blood, Male, Middle Aged, Myocardial Infarction/blood, Retrospective Studies, Severity of Illness Index, Tryptases/blood, Young Adult, Autopsy, Coronary artery disease, Forensic, IgE, Postmortem biochemistry
Pubmed
Web of science
Création de la notice
23/01/2019 11:44
Dernière modification de la notice
20/08/2019 15:49