Mortality among 24,865 workers exposed to polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: a ten-year update

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_8AD5E151F7A6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mortality among 24,865 workers exposed to polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: a ten-year update
Périodique
International Journal of Hygiene and Environmental Health
Auteur(s)
Ruder Avima M., Hein Misty J., Hopf Nancy B., Waters Martha A.
ISSN
1618-131X (Electronic)
ISSN-L
1438-4639
Statut éditorial
Publié
Date de publication
03/2014
Peer-reviewed
Oui
Volume
217
Numéro
2-3
Pages
176-187
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
The objective of this analysis was to evaluate mortality among a cohort of 24,865 capacitor-manufacturing workers exposed to polychlorinated biphenyls (PCBs) at plants in Indiana, Massachusetts, and New York and followed for mortality through 2008. Cumulative PCB exposure was estimated using plant-specific job-exposure matrices. External comparisons to US and state-specific populations used standardized mortality ratios, adjusted for gender, race, age and calendar year. Among long-term workers employed 3 months or longer, within-cohort comparisons used standardized rate ratios and multivariable Poisson regression modeling. Through 2008, more than one million person-years at risk and 8749 deaths were accrued. Among long-term employees, all-cause and all-cancer mortality were not elevated; of the a priori outcomes assessed only melanoma mortality was elevated. Mortality was elevated for some outcomes of a priori interest among subgroups of long-term workers: all cancer, intestinal cancer and amyotrophic lateral sclerosis (women); melanoma (men); melanoma and brain and nervous system cancer (Indiana plant); and melanoma and multiple myeloma (New York plant). Standardized rates of stomach and uterine cancer and multiple myeloma mortality increased with estimated cumulative PCB exposure. Poisson regression modeling showed significant associations with estimated cumulative PCB exposure for prostate and stomach cancer mortality. For other outcomes of a priori interest--rectal, liver, ovarian, breast, and thyroid cancer, non-Hodgkin lymphoma, Alzheimer disease, and Parkinson disease--neither elevated mortality nor positive associations with PCB exposure were observed. Associations between estimated cumulative PCB exposure and stomach, uterine, and prostate cancer and myeloma mortality confirmed our previous positive findings.

Mots-clé
Adult, Amyotrophic Lateral Sclerosis/mortality, Cause of Death, Cohort Studies, Female, Humans, Indiana/epidemiology, Industry, Male, Massachusetts/epidemiology, Melanoma/mortality, Multiple Myeloma/mortality, Neoplasms/mortality, New York/epidemiology, Occupational Diseases/mortality, Occupational Exposure/adverse effects, Occupations, Polychlorinated Biphenyls/adverse effects, Sex Factors, Young Adult, Cancer, Cohort study, Exposure assessment, Occupational exposure, Polychlorinated biphenyls
Pubmed
Web of science
Création de la notice
06/05/2013 13:14
Dernière modification de la notice
20/08/2019 15:49
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