Marijuana Use and Estimated Glomerular Filtration Rate in Young Adults.

Détails

ID Serval
serval:BIB_8ABBFD4E6F4A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Marijuana Use and Estimated Glomerular Filtration Rate in Young Adults.
Périodique
Clinical journal of the American Society of Nephrology
Auteur(s)
Ishida J.H., Auer R., Vittinghoff E., Pletcher M.J., Reis J.P., Sidney S., Johansen K.L., Bibbins-Domingo K., Peralta C.A., Shlipak M.G.
ISSN
1555-905X (Electronic)
ISSN-L
1555-9041
Statut éditorial
Publié
Date de publication
06/10/2017
Peer-reviewed
Oui
Volume
12
Numéro
10
Pages
1578-1587
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Résumé
Marijuana use has become more widely accepted in the United States and has been legalized in many areas. Although it is biologically plausible that marijuana could affect kidney function, epidemiologic data are lacking.
We conducted a cohort study among young adults with preserved eGFR ( <i>i.e.</i> , eGFR≥60 ml/min per 1.73 m <sup>2</sup> ) using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study. At scheduled examinations occurring every 5 years and starting at study year 10 (calendar years, 1995-1996), cystatin C was collected over a 10-year period, and urine albumin-to-creatinine ratio was collected over a 15-year period. We investigated the cross-sectional association between current and cumulative marijuana use (in marijuana-years; one marijuana-year equals 365 days of marijuana use) and eGFR by cystatin C (eGFR <sub>cys</sub> ) at year 10. In longitudinal analyses, we investigated the association between cumulative marijuana use and eGFR <sub>cys</sub> change and rapid (≥3%/year) eGFR <sub>cys</sub> decline over two 5-year intervals and prevalent albuminuria (urine albumin-to-creatinine ratio ≥30 mg/g) over a 15-year period.
Past or current marijuana use was reported by 83% (3131 of 3765) of the cohort, and the mean eGFR <sub>cys</sub> was 111 ml/min per 1.73 m <sup>2</sup> at year 10. Over the following 10 years, 504 had rapid eGFR <sub>cys</sub> decline, and over the following 15 years, 426 had prevalent albuminuria. Compared with no use, daily current use and ≥5 marijuana-years of cumulative use were associated with lower eGFR <sub>cys</sub> at year 10: -4.5% (95% confidence interval, -8.1 to -0.7%; <i>P</i> =0.02) and -3.0% (95% confidence interval, -5.6 to -0.4%; <i>P</i> =0.03), respectively. Marijuana use was not significantly associated with eGFR <sub>cys</sub> change, rapid eGFR <sub>cys</sub> decline, or prevalent albuminuria.
Although we identified a modest cross-sectional association between higher marijuana exposure and lower eGFR <sub>cys</sub> among young adults with preserved eGFR, our findings were largely null and did not demonstrate a longitudinal association between marijuana use and eGFR <sub>cys</sub> change, rapid eGFR <sub>cys</sub> decline, or prevalent albuminuria.
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_08_24_CJASNPodcast_17_10.mp3.
Mots-clé
Adolescent, Adult, Age Factors, Albuminuria/etiology, Albuminuria/physiopathology, Biomarkers/blood, Biomarkers/urine, Comorbidity, Creatinine/urine, Cross-Sectional Studies, Cystatin C/blood, Female, Glomerular Filtration Rate, Humans, Kidney/physiopathology, Kidney Diseases/diagnosis, Kidney Diseases/epidemiology, Kidney Diseases/physiopathology, Longitudinal Studies, Male, Marijuana Abuse/diagnosis, Marijuana Abuse/epidemiology, Marijuana Abuse/physiopathology, Marijuana Smoking/adverse effects, Marijuana Smoking/epidemiology, Marijuana Smoking/physiopathology, Prevalence, Risk Factors, Socioeconomic Factors, Time Factors, United States/epidemiology, Young Adult, Albumins, Cannabis, Cohort Studies, Coronary Vessels, Cystatin C, EGFR protein, human, Kidney Function Tests, Marijuana, Marijuana Abuse, Marijuana Smoking, Receptor, Epidermal Growth Factor, United States, albuminuria, clinical epidemiology, creatinine, glomerular filtration rate, kidney disease
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/10/2017 16:36
Dernière modification de la notice
20/08/2019 14:49
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