Cancer wars: natural products strike back.

Détails

ID Serval
serval:BIB_8A7C6F1DBBD8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cancer wars: natural products strike back.
Périodique
Frontiers in Chemistry
Auteur(s)
Basmadjian C., Zhao Q., Bentouhami E., Djehal A., Nebigil C.G., Johnson R.A., Serova M., de Gramont A., Faivre S., Raymond E., Désaubry L.G.
ISSN
2296-2646 (Electronic)
ISSN-L
2296-2646
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
2
Pages
20
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: epublish
Résumé
Natural products have historically been a mainstay source of anticancer drugs, but in the 90's they fell out of favor in pharmaceutical companies with the emergence of targeted therapies, which rely on antibodies or small synthetic molecules identified by high throughput screening. Although targeted therapies greatly improved the treatment of a few cancers, the benefit has remained disappointing for many solid tumors, which revitalized the interest in natural products. With the approval of rapamycin in 2007, 12 novel natural product derivatives have been brought to market. The present review describes the discovery and development of these new anticancer drugs and highlights the peculiarities of natural product and new trends in this exciting field of drug discovery.
Pubmed
Open Access
Oui
Création de la notice
11/02/2015 13:14
Dernière modification de la notice
20/08/2019 15:49
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