Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis.

Détails

ID Serval
serval:BIB_8A5414AD1E48
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis.
Périodique
Head & neck
Auteur(s)
Mermod M., Bongiovanni M., Petrova T.V., Dubikovskaya E.A., Simon C., Tolstonog G., Monnier Y.
ISSN
1097-0347 (Electronic)
ISSN-L
1043-3074
Statut éditorial
Publié
Date de publication
01/2017
Peer-reviewed
Oui
Volume
39
Numéro
1
Pages
98-108
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The correlation between podoplanin expression and extracapsular spread in head and neck squamous cell carcinoma (HNSCC) has never been reported. The purpose of this study was to assess the predictive value of podoplanin expression for this parameter.
Subjective immunoreactivity scores and semiquantitative image analysis of podoplanin expression were performed in 67 patients with primary oral squamous cell carcinoma and in their corresponding lymph nodes. Neck classification showed 34 cases (51%) of pN0 and 33 cases (49%) of pN+. Correlation between the levels of podoplanin expression and the histopathological data was established.
In lymph nodes, a high level of podoplanin expression correlated with the presence of extracapsular spread by multivariate analysis (p = .03). A strong correlation between subjective and semiquantitative image analysis was observed (r = 0.77; p < .001).
A high level of podoplanin expression in lymph node metastases of oral squamous cell carcinoma is independently associated with extracapsular spread. © 2016 Wiley Periodicals, Head Neck 39: 98-108, 2017.

Mots-clé
Adult, Aged, Aged, 80 and over, Biomarkers/metabolism, Carcinoma, Squamous Cell/metabolism, Carcinoma, Squamous Cell/pathology, Female, Humans, Male, Membrane Glycoproteins/metabolism, Middle Aged, Mouth Neoplasms/metabolism, Mouth Neoplasms/pathology, Neoplasm Invasiveness, Neoplasm Staging, Predictive Value of Tests, Retrospective Studies, extracapsular spread, head and neck squamous cell carcinoma, podoplanin, prognosis
Pubmed
Web of science
Création de la notice
06/12/2016 9:37
Dernière modification de la notice
20/08/2019 14:49
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