Primate adult brain cell autotransplantation, a pilot study in asymptomatic MPTP-treated monkeys.

Détails

Ressource 1Télécharger: BIB_8A1A3CFC7664.P001.pdf (7011.60 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_8A1A3CFC7664
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Primate adult brain cell autotransplantation, a pilot study in asymptomatic MPTP-treated monkeys.
Périodique
Cell Transplantation
Auteur⸱e⸱s
Brunet J.F., Redmond D.E., Bloch J.
ISSN
1555-3892[electronic], 0963-6897[linking]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
18
Numéro
7
Pages
787-799
Langue
anglais
Résumé
Autologous brain cell transplantation might be useful for repairing lesions and restoring function of the central nervous system. We have demonstrated that adult monkey brain cells, obtained from cortical biopsy and kept in culture for a few weeks, exhibit neural progenitor characteristics that make them useful for brain repair. Following MPTP treatment, primates were dopamine depleted but asymptomatic. Autologous cultured cells were reimplanted into the right caudate nucleus of the donor monkey. Four months after reimplantation, histological analysis by stereology and TH immunolabeling showed that the reimplanted cells successfully survived, bilaterally migrated in the whole striatum, and seemed to have a neuroprotection effect over time. These results may add a new strategy to the field of brain neuroprotection or regeneration and could possibly lead to future clinical applications.
Mots-clé
Adult brain cells, Autograft, MPTP-treated monkeys, Embryonic Stem-Cells, Central-Nervous-System, Severe Parkinsons-Disease, Neural Progenitor Cells, Dopamine Neurons, Rat-Brain, Defined Factors, Transplantation, Survival, Model
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/11/2009 14:38
Dernière modification de la notice
20/08/2019 14:49
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