Antihypertensive therapy with MK 421: angiotensin II--renin relationships to evaluate efficacy of converting enzyme blockade

Détails

ID Serval
serval:BIB_8A0CF67C5294
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antihypertensive therapy with MK 421: angiotensin II--renin relationships to evaluate efficacy of converting enzyme blockade
Périodique
Journal of Cardiovascular Pharmacology
Auteur(s)
Biollaz  J., Brunner  H. R., Gavras  I., Waeber  B., Gavras  H.
ISSN
0160-2446 (Print)
Statut éditorial
Publié
Date de publication
12/1982
Volume
4
Numéro
6
Pages
966-72
Notes
Journal Article --- Old month value: Nov-Dec
Résumé
Nineteen hypertensive patients were treated with increasing doses of the new angiotensin-converting enzyme inhibitor MK 421. Twenty milligrams orally reduced blood pressure from 180/112 +/- 6.8/3.6 (mean +/- SEM) to 160/100 +/- 6.5/3.3 mm Hg (p less than 0.005) while heart rate increased from 75 +/- 2 to 87 +/- 3 beats/min (p less than 0.005). Plasma converting enzyme activity was still markedly reduced 24 h following 2.5, 5, 10, or 20 mg MK 421 p.o. (p less than 0.001). In nine patients treated with 20 mg b.i.d. for up to 10 months, blood pressure was controlled, with the association of hydrochlorothiazide 50 mg q.d. in five. However, 12 to 16 h following the preceding drug administration, plasma angiotensin II and aldosterone were back to base-line levels. Analysis of plasma angiotensin II-renin relationships strongly suggests that converting enzyme blockade is not complete even 4 h after 20 mg MK 421 and starts to wear off already at 12 h. Thus, MK 421 20 mg taken orally twice daily, effectively reduces blood pressure, but does not constantly suppress plasma angiotensin II and aldosterone. Whether its long duration of action makes once daily administration possible has not yet been established.
Mots-clé
Adult Aged Aldosterone/blood Angiotensin II/*blood *Angiotensin-Converting Enzyme Inhibitors Blood Pressure/drug effects Dipeptides/*pharmacology Dose-Response Relationship, Drug Drug Therapy, Combination Enalapril Female Heart Rate/drug effects Humans Hydrochlorothiazide/pharmacology Hypertension/*drug therapy Male Middle Aged Renin/*blood Renin-Angiotensin System/drug effects
Pubmed
Web of science
Création de la notice
25/01/2008 10:41
Dernière modification de la notice
20/08/2019 14:48
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