Compartmentalized secretory leukocyte protease inhibitor expression and hormone responses along the reproductive tract of postmenopausal women

Détails

ID Serval
serval:BIB_89FBD702612A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Compartmentalized secretory leukocyte protease inhibitor expression and hormone responses along the reproductive tract of postmenopausal women
Périodique
Journal of reproductive immunology
Auteur(s)
Kumar R., Vicari M., Gori I., Achtari C., Fiche M., Surbeck I., Damnon F., Canny G.O.
ISSN
1872-7603 (Electronic)
ISSN-L
0165-0378
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
92
Numéro
1-2
Pages
88-96
Langue
anglais
Résumé
Immunity and hormonal responses in the reproductive tissues of postmenopausal women are poorly understood. Secretory leukocyte protease inhibitor (SLPI), a multifunctional antimicrobial protein expressed at mucosal surfaces, is thought to play a key role in infectious and inflammatory contexts. The aim of this study was to measure SLPI production along the female reproductive tract in postmenopausal women with and without hormonal treatment. We additionally quantified estrogen receptor alpha (ERα) and progesterone receptor A (PRA) in these tissues. Expression of SLPI was decreased in the vagina and ectocervix of women under hormonal treatment. Endocervical ERα mRNA expression was increased while this did not reach significance at the protein level. SLPI expression in the endometrium was not influenced by hormonal treatment. We observed attenuated ERα expression in the cervix and endometrium of hormonally treated women, whereas vaginal expression was increased. PRA expression was augmented in the cervix and endometrium and unchanged in the vagina. Taken together, our results indicate that hormonal responses and receptor expression are differentially regulated in vaginal tissue compared with the cervix and endometrium.
Pubmed
Web of science
Création de la notice
27/09/2011 21:22
Dernière modification de la notice
20/08/2019 14:48
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