Follow up of T cells subsets and anti-trisaccharide IgM antibody levels of leprosy patients during daily multidrug therapy.

Détails

ID Serval
serval:BIB_89C6436B742D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Follow up of T cells subsets and anti-trisaccharide IgM antibody levels of leprosy patients during daily multidrug therapy.
Périodique
Acta Leprologica
Auteur⸱e⸱s
Desforges S., Launois P., Bobin P., Bach M.A.
ISSN
0001-5938 (Print)
ISSN-L
0001-5938
Statut éditorial
Publié
Date de publication
1989
Volume
7
Numéro
Suppl 1
Pages
169-170
Langue
anglais
Résumé
T cell subset distribution and anti-M. leprae specific antibody levels were followed in leprosy patients during polychemotherapy (or multidrug therapy, MDT). Before treatment, the T cell subset counts showed that the multibacillary patients (28) have a significant decrease (p less than 0.05) in the CD3+, CD4+ T percentages and CD4+/CD8+ ratio as compared to the healthy controls (96). The paucibacillary patients (30) had no significant T cell disturbances. An ELISA test has been developed using the natural trisaccharide-ocytl-BSA (NTO) antigen to identify specific IgM antibodies (IgM anti-T). Multibacillary patients (22) showed higher antibody titers than paucibacillary patients (11). But the IgM anti-T levels of the two groups are significantly higher than controls belonging to the same ethnic group. A daily polychemotherapy (Dapsone, Rifampicine, Clofazimine) was done for 6 months in paucibacillary patients and 2 years in multibacillary patients according to the leprosy group study recommendations (Prof. Grosset, Hôptical de la Salpêtrière, Paris, France). A normalization of the CD4+ T cells was obtained by a 6 month therapy in multibacillary patients and a significant decrease in the IgM anti-levels was obtained during polychemotherapy in multibacillaries (p less than 0.001) and paucibacillaries (p less than 0.05).
Mots-clé
Antibodies, Bacterial/analysis, Humans, Immunoglobulin M/analysis, Leprostatic Agents/therapeutic use, Leprosy/blood, Leprosy/drug therapy, Leukocyte Count, Mycobacterium leprae/immunology, T-Lymphocytes/classification, T-Lymphocytes/immunology, Trisaccharides/immunology
Pubmed
Création de la notice
28/01/2008 11:06
Dernière modification de la notice
20/08/2019 14:48
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