Vitamin E supplementation reduces plasma vascular cell adhesion molecule-1 and von Willebrand factor levels and increases nitric oxide concentrations in hypercholesterolemic patients.

Détails

ID Serval
serval:BIB_899BB69D54AE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Vitamin E supplementation reduces plasma vascular cell adhesion molecule-1 and von Willebrand factor levels and increases nitric oxide concentrations in hypercholesterolemic patients.
Périodique
The Journal of clinical endocrinology and metabolism
Auteur(s)
Desideri G., Marinucci M.C., Tomassoni G., Masci P.G., Santucci A., Ferri C.
ISSN
0021-972X (Print)
ISSN-L
0021-972X
Statut éditorial
Publié
Date de publication
06/2002
Peer-reviewed
Oui
Volume
87
Numéro
6
Pages
2940-2945
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Résumé
Up-regulation of vascular cell adhesion molecule-1 (VCAM-1) and reduced nitric oxide (NO) availability represent early characteristics of atherosclerosis. To evaluate whether the antioxidant vitamin E affected the circulating levels of soluble VCAM-1 (sVCAM-1) and the plasma metabolite of NO (nitrite+nitrate) in hypercholesterolemic patients, either vitamin E (either 400 IU or 800 IU/d for 8 wk) or placebo were randomly, double-blindly given to 36 hypercholesterolemic patients and 22 age- and sex-matched controls. At baseline hypercholesterolemic patients showed higher plasma sVCAM-1 (microg.liter(-1)) (591.2 +/- 132.5 vs. 505.0 +/- 65.6, P < 0.007) and lower NO metabolite (microM) levels (15.9 +/- 3.4 vs. 29.2 +/- 5.1, P < 0.0001) than controls. In hypercholesterolemic patients, 8 wk vitamin E (but not placebo) treatment significantly decreased circulating sVCAM-1 levels (400 IU: -148.9 +/- 84.6, P < 0.009; 800 IU: -204.0 +/- 75.7, P < 0.0001; placebo: -4.7 +/- 22.6, NS), whereas it increased NO metabolite concentrations (400 IU: +4.0 +/- 1.7, P < 0.02; 800 IU: +5.5 +/- 0.8, P < 0.0001; placebo: +0.1 +/- 1.1, NS) without affecting circulating low- density lipoprotein levels. Changes in both plasma sVCAM-1 and NO metabolite levels showed a trend to significantly correlate (r = -0.515, P = 0.010; and r = 0.435, P = 0.034, respectively) with changes in vitamin E concentrations induced by vitamin E supplementation. In conclusion, isolated hypercholesterolemia both increased circulating sVCAM-1 and reduced NO metabolite concentrations. Vitamin E supplementation counteracts these alterations, thus representing a potential tool for endothelial protection in hypercholesterolemic patients.

Mots-clé
Adult, Antioxidants/administration & dosage, Antioxidants/therapeutic use, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Hypercholesterolemia/blood, Hypercholesterolemia/drug therapy, Male, Middle Aged, Nitric Oxide/blood, Osmolar Concentration, Reference Values, Solubility, Vascular Cell Adhesion Molecule-1/blood, Vitamin E/administration & dosage, Vitamin E/therapeutic use, von Willebrand Factor/analysis
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/08/2017 21:03
Dernière modification de la notice
20/08/2019 14:48
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