7,12-Dimethylbenz[a]anthracene-induced 'early' squamous cell carcinoma in the golden syrian hamster: Evaluation of an animal model and comparison with 'early' forms of human squamous cell carcinoma in the upper aero-digestive tract

Détails

ID Serval
serval:BIB_8977D2F0D0C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
7,12-Dimethylbenz[a]anthracene-induced 'early' squamous cell carcinoma in the golden syrian hamster: Evaluation of an animal model and comparison with 'early' forms of human squamous cell carcinoma in the upper aero-digestive tract
Périodique
International Journal of Experimental Pathology
Auteur⸱e⸱s
Andrejevic S., Savary J. F., Fontolliet C., Monnier P., van den Bergh H.
ISSN
0959-9673
Statut éditorial
Publié
Date de publication
02/1996
Peer-reviewed
Oui
Volume
77
Numéro
1
Pages
7-14
Langue
anglais
Résumé
To test and optimize photodynamic therapy of early cancers in the upper aero-digestive tract and oesophagus, we sought an appropriate animal model, which was found in the 7,12-dimethylbenz[a]anthracene-induced early squamous cell carcinoma in the Golden Syrian hamster. This chemically induced neoplasm is shown, by histology and immunohistochemistry, to pass through similar stages of early cancer development as its human counterpart. Its time sequence is highly reproducible, leading to a well differentiated carcinoma in situ and microinvasive carcinoma in the hamster cheek pouch over a period of 10 weeks.
Pubmed
Web of science
Création de la notice
14/12/2008 10:03
Dernière modification de la notice
20/08/2019 15:48
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