Regenerative cell injection in denervated muscle reduces atrophy and enhances recovery following nerve repair.

Détails

ID Serval
serval:BIB_8972A3134C4C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Regenerative cell injection in denervated muscle reduces atrophy and enhances recovery following nerve repair.
Périodique
Muscle and Nerve
Auteur(s)
Schaakxs D., Kalbermatten D.F., Raffoul W., Wiberg M., Kingham P.J.
ISSN
1097-4598 (Electronic)
ISSN-L
0148-639X
Statut éditorial
Publié
Date de publication
2013
Volume
47
Numéro
5
Pages
691-701
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. PDF type: Research Article
Résumé
INTRODUCTION: Functional muscle recovery after peripheral nerve injury is far from optimal, partly due to atrophy of the muscle arising from prolonged denervation. We hypothesized that injecting regenerative cells into denervated muscle would reduce this atrophy.
METHODS: A rat sciatic nerve lesion was performed, and Schwann cells or adipose-derived stem cells, untreated or induced to a "Schwann-cell-like" phenotype (dASC), were injected into the gastrocnemius muscle. Nerves were either repaired immediately or capped to prevent muscle reinnervation. One month later, functionality was measured using a walking track test, and muscle atrophy was assessed by examining muscle weight and histology.
RESULTS: Schwann cells and dASC groups showed significantly better scores on functional tests when compared with injections of growth medium alone. Muscle weight and histology were also significantly improved in these groups.
CONCLUSION: Cell injections may reduce muscle atrophy and could benefit nerve injury patients.
Pubmed
Web of science
Création de la notice
06/06/2013 18:07
Dernière modification de la notice
20/08/2019 14:48
Données d'usage